α-mt对氯丙嗪致热疗的影响

International journal of neuropharmacology Pub Date : 1969-07-01 DOI:10.1016/0028-3908(69)90026-4

W.J. Rewerski , W. Gumulka

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引用次数: 7

摘要

α-MT给药4次，每次50 mg/kg，每次间隔4小时，可降低大鼠体温。α-MT预处理动物下丘脑前部注射CPZ引起的高热效应持续存在。因此，CPZ的热作用机制更可能是由于CPZ的直接作用，而不是与NA的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The effect of α-mt on hyperthermia induced by chlorpromazine

Administration of α-MT (four separate doses of 50 mg/kg with 4 hr interval between each injection) lowered the body temperature of rats. Hyperthermic effects induced by CPZ injection into the anterior part of hypothalamus persist in animals pretreated with α-MT. It is suggested therefore that the mechanism for the hyperthermic action of CPZ is more likely to be due to a direct effect of CPZ than with its interaction with NA.

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International journal of neuropharmacology

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