{"title":"太阳灭活伤寒抗原的免疫原性","authors":"B.A. Ngwu , J.A.C. Agboz , C.E. Anyiwo","doi":"10.1016/0888-0786(95)97897-E","DOIUrl":null,"url":null,"abstract":"<div><p>The purpose of this study was to explore the antigenic potential of solar-inactivated typhoid antigens and compare them with those produced by acetone treatment. The agglutination titre levels of 1 :512, 1 :256 and 1 :256 were observed with antigens produced by 8 h, 8.5 h and 9 h exposure to the sun, respectively. This was compared with the agglutination titre levels of 1 : 128, 1 : 256 and 1 : 512 produced by 5 : 1 vol/vol, 3 : 1 vol/vol and 2 : 1 vol/vol acetone inactivation respectively. This result showed that high immunogenic, cost effective typhoid antigens can be produced with solar energy. This information can be exploited in future formulation of typhoid vaccine and for serodiagnosis.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 133-134"},"PeriodicalIF":0.0000,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97897-E","citationCount":"0","resultStr":"{\"title\":\"Immunogenic potential of solar-inactivated typhoid antigens\",\"authors\":\"B.A. Ngwu , J.A.C. Agboz , C.E. Anyiwo\",\"doi\":\"10.1016/0888-0786(95)97897-E\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The purpose of this study was to explore the antigenic potential of solar-inactivated typhoid antigens and compare them with those produced by acetone treatment. The agglutination titre levels of 1 :512, 1 :256 and 1 :256 were observed with antigens produced by 8 h, 8.5 h and 9 h exposure to the sun, respectively. This was compared with the agglutination titre levels of 1 : 128, 1 : 256 and 1 : 512 produced by 5 : 1 vol/vol, 3 : 1 vol/vol and 2 : 1 vol/vol acetone inactivation respectively. This result showed that high immunogenic, cost effective typhoid antigens can be produced with solar energy. This information can be exploited in future formulation of typhoid vaccine and for serodiagnosis.</p></div>\",\"PeriodicalId\":101161,\"journal\":{\"name\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"volume\":\"7 3\",\"pages\":\"Pages 133-134\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0888-0786(95)97897-E\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/088807869597897E\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Serodiagnosis and Immunotherapy in Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088807869597897E","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunogenic potential of solar-inactivated typhoid antigens
The purpose of this study was to explore the antigenic potential of solar-inactivated typhoid antigens and compare them with those produced by acetone treatment. The agglutination titre levels of 1 :512, 1 :256 and 1 :256 were observed with antigens produced by 8 h, 8.5 h and 9 h exposure to the sun, respectively. This was compared with the agglutination titre levels of 1 : 128, 1 : 256 and 1 : 512 produced by 5 : 1 vol/vol, 3 : 1 vol/vol and 2 : 1 vol/vol acetone inactivation respectively. This result showed that high immunogenic, cost effective typhoid antigens can be produced with solar energy. This information can be exploited in future formulation of typhoid vaccine and for serodiagnosis.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
