Jan M Federspiel, Frank Ramsthaler, Mattias Kettner, Gerhard Mall
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Diagnostics of messenger ribonucleic acid (mRNA) severe acute respiratory syndrome-corona virus‑2 (SARS-CoV‑2) vaccination-associated myocarditis-A systematic review.
Background: During the recent pandemic with the severe acute respiratory syndrome-corona virus‑2 the first messenger ribonucleic acid (mRNA) vaccines were approved. To facilitate mass vaccination, confidence of the general population in these new vaccines is mandatory, which is in turn strongly dependent on the availability of reliable data on complications.
Objective: Summary of the current knowledge on mRNA vaccination-associated myocarditis as a potentially fatal side effect.
Methods: Systematic literature review.
Results: Diagnostic algorithm for the postmortem diagnosis of mRNA vaccination-associated myocarditis.
Conclusion: Autopsy series of fatalities following mRNA SARS-CoV‑2 vaccination up to 6 weeks with subsequent sophisticated and interdisciplinary work-up are necessary to complement clinical data on vaccination-associated myocarditis, especially regarding the incidence of fatal courses.
Supplementary information: The online version of this article (10.1007/s00194-022-00587-9) includes a PDF file with supplemental clinical features.
期刊介绍：
Rechtsmedizin is an internationally recognized journal dealing with all aspects of forensic medicine. It provides information on current developments in forensic pathology, traumatology, traffic medicine, toxicology, serology, insurance medicine, psychopathology and legal medical issues.
Freely submitted original papers allow the presentation of important clinical studies and serve scientific exchange.
Case reports feature interesting and unique cases thus providing a platform for scientific information and critical discussion.
Comprehensive reviews on a specific topical issue focus on providing evidenced based information on all aspects of the field.
Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.
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