腹侧苍白球中的组胺及其H1受体通过该区域和脊髓阿片受体介导福尔马林诱导的疼痛相关行为。

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2023-12-01 Epub Date: 2023-03-06 DOI:10.1097/FBP.0000000000000724
Morteza Asgharieh-Ahari, Esmaeal Tamaddonfard, Amir Erfanparast, Farhad Soltanalinejad-Taghiabad
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引用次数: 1

摘要

中枢神经系统的许多结构在疼痛处理中募集不同的神经递质。本研究的重点是腹侧苍白球(VP)中组胺及其H1受体在介导疼痛触发行为中的作用。VP内微量注射组胺和2-吡啶基乙胺(2-PEA,一种组胺H1受体激动剂),剂量分别为0.5和1 µg/200 nl降低了舔/咬持续时间的第一阶段和第二阶段,以及由足底内注射福尔马林(2.5%,50 µl)。甲吡拉明(组胺H1拮抗剂,2 µg/200 nl)进入VP拮抗1 µg/200 nl-组胺和2-PEA对舔/咬和退缩行为的影响。对上述止痛作用的可能机制进行了VP内和鞘内给药纳洛酮(一种阿片受体拮抗剂)的研究。纳洛酮(2 µg/200 nl)VP预给药抑制组胺和2-PEA对舔/咬和退缩行为的减弱作用,而鞘内注射纳洛酮仅抑制其对退缩行为的抑制作用。这项研究中使用的任何治疗方法都没有改变动物的运动活动。研究结果可能揭示组胺及其激活的H1受体在VP中抑制福尔马林引起的疼痛行为中的作用。VP和脊髓中的阿片受体可能有助于这些功能。
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Histamine and its H 1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors.

Many structures of the central nervous system recruit different neurotransmitters in pain processing. This study focused on the contribution of histamine and its H 1 receptors in the ventral pallidum (VP) in mediating pain-triggered behaviors. Intra-VP microinjection of histamine and 2-pyridylethylamine (2-PEA, a histamine H 1 receptor agonist) at the same doses of 0.5 and 1 µg/200 nl reduced both the first and second phases of licking/biting duration as well as flinching number induced by intra-plantar (ipl) injection of formalin (2.5%, 50 µl). Premicroinjection of mepyramine (a histamine H 1 antagonist, 2 µg/200 nl) into the VP antagonized the suppressive effects of 1 µg/200 nl histamine and 2-PEA on licking/biting and flinching behaviors. The possible mechanisms of the above-mentioned pain-reducing effects were followed by intra-VP and intrathecal administration of naloxone (an opioid receptor antagonist). Naloxone (2 µg/200 nl) preadministration into the VP inhibited attenuating effects of histamine and 2-PEA on both the licking/biting and flinching behaviors, whereas intrathecal injection of naloxone only inhibited their suppressing effects on flinching behavior. None of the treatments used in this study altered the animal's motor activity. The obtained results may reveal the role of histamine and its activated H 1 receptor in the VP in suppressing the pain behaviors caused by formalin. Opioid receptors in the VP and spinal cord may contribute to these functions.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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