I. Banzo , R. Quirce , I. Martínez-Rodríguez , J. Jiménez-Bonilla , H. Portilla-Quattrociocchi , P. Medina-Quiroz , F. Ortega , E. Rodríguez , I. Mateo , J.L. Vázquez-Higuera , M. de Arcocha , J.M. Carril
{"title":"分子神经影像学在认知障碍研究中的作用:99mTc-HMPAO和18F-FDG PET/CT脑血流SPECT的贡献","authors":"I. Banzo , R. Quirce , I. Martínez-Rodríguez , J. Jiménez-Bonilla , H. Portilla-Quattrociocchi , P. Medina-Quiroz , F. Ortega , E. Rodríguez , I. Mateo , J.L. Vázquez-Higuera , M. de Arcocha , J.M. Carril","doi":"10.1016/j.remngl.2011.03.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study was to analyze cerebral perfusion and glucose metabolism in patients with cognitive impairment using cerebral blood flow <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans.</p></div><div><h3>Material and methods</h3><p>Twenty-two patients with cognitive impairment were included: 4 subjective memory complaints (SMC), 8 amnestic mild cognitive impairment (MCI), 5 prodromic Alzheimer's disease (AD) and 5 AD. In each clinical group, <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans were performed.</p></div><div><h3>Results</h3><p><sup>99m</sup>Tc-HMPAO SPECT showed regions of cerebral hypoperfusion in 15 patients and was normal in 7 of the 22 patients. <sup>18</sup>F-FDG PET/CT scan showed cerebral regional hypometabolism in 19 patients and was normal in the other 3 patients. The distribution of abnormalities on <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans was similar in 9 patients (2 SMC, 2 amnestic MCI, 2 prodromic AD, and 3 AD). In 6 patients (1 amnestic MCI, 2 prodromic AD, and 3 AD), FDG hypometabolism was more extensive than the cerebral hypoperfusion. Four patients (1 SMC, 3 amnestic MCI) had an abnormal <sup>18</sup>F-FDG PET/CT scan and normal <sup>99m</sup>Tc-HMPAO SPECT. There were 3 patients (1 SMC, 2 amnestic MCI) with normal <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans.</p></div><div><h3>Conclusion</h3><p><sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans showed cerebral hypoperfusion and hypometabolism in patients with cognitive impairment, even in patients with clinical diagnosis of SMC. In patients with a normal cerebral blood flow SPECT, brain glucose cerebral hypometabolism can be detected. In some patients, the extension of FDG hypometabolism is more pronounced than that corresponding to the hypoperfusion area.</p></div>","PeriodicalId":101111,"journal":{"name":"Revista Espa?ola de Medicina Nuclear (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.remngl.2011.03.011","citationCount":"5","resultStr":"{\"title\":\"Molecular Neuroimaging in the Study of Cognitive Impairment: Contribution of the Cerebral Blood Flow SPECT with 99mTc-HMPAO and 18F-FDG PET/CT Scan\",\"authors\":\"I. Banzo , R. Quirce , I. Martínez-Rodríguez , J. Jiménez-Bonilla , H. Portilla-Quattrociocchi , P. Medina-Quiroz , F. Ortega , E. Rodríguez , I. Mateo , J.L. Vázquez-Higuera , M. de Arcocha , J.M. Carril\",\"doi\":\"10.1016/j.remngl.2011.03.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The aim of this study was to analyze cerebral perfusion and glucose metabolism in patients with cognitive impairment using cerebral blood flow <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans.</p></div><div><h3>Material and methods</h3><p>Twenty-two patients with cognitive impairment were included: 4 subjective memory complaints (SMC), 8 amnestic mild cognitive impairment (MCI), 5 prodromic Alzheimer's disease (AD) and 5 AD. In each clinical group, <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans were performed.</p></div><div><h3>Results</h3><p><sup>99m</sup>Tc-HMPAO SPECT showed regions of cerebral hypoperfusion in 15 patients and was normal in 7 of the 22 patients. <sup>18</sup>F-FDG PET/CT scan showed cerebral regional hypometabolism in 19 patients and was normal in the other 3 patients. The distribution of abnormalities on <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans was similar in 9 patients (2 SMC, 2 amnestic MCI, 2 prodromic AD, and 3 AD). In 6 patients (1 amnestic MCI, 2 prodromic AD, and 3 AD), FDG hypometabolism was more extensive than the cerebral hypoperfusion. Four patients (1 SMC, 3 amnestic MCI) had an abnormal <sup>18</sup>F-FDG PET/CT scan and normal <sup>99m</sup>Tc-HMPAO SPECT. There were 3 patients (1 SMC, 2 amnestic MCI) with normal <sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans.</p></div><div><h3>Conclusion</h3><p><sup>99m</sup>Tc-HMPAO SPECT and <sup>18</sup>F-FDG PET/CT scans showed cerebral hypoperfusion and hypometabolism in patients with cognitive impairment, even in patients with clinical diagnosis of SMC. In patients with a normal cerebral blood flow SPECT, brain glucose cerebral hypometabolism can be detected. In some patients, the extension of FDG hypometabolism is more pronounced than that corresponding to the hypoperfusion area.</p></div>\",\"PeriodicalId\":101111,\"journal\":{\"name\":\"Revista Espa?ola de Medicina Nuclear (English Edition)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.remngl.2011.03.011\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Espa?ola de Medicina Nuclear (English Edition)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1578200X11000581\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Espa?ola de Medicina Nuclear (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1578200X11000581","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular Neuroimaging in the Study of Cognitive Impairment: Contribution of the Cerebral Blood Flow SPECT with 99mTc-HMPAO and 18F-FDG PET/CT Scan
Objective
The aim of this study was to analyze cerebral perfusion and glucose metabolism in patients with cognitive impairment using cerebral blood flow 99mTc-HMPAO SPECT and 18F-FDG PET/CT scans.
Material and methods
Twenty-two patients with cognitive impairment were included: 4 subjective memory complaints (SMC), 8 amnestic mild cognitive impairment (MCI), 5 prodromic Alzheimer's disease (AD) and 5 AD. In each clinical group, 99mTc-HMPAO SPECT and 18F-FDG PET/CT scans were performed.
Results
99mTc-HMPAO SPECT showed regions of cerebral hypoperfusion in 15 patients and was normal in 7 of the 22 patients. 18F-FDG PET/CT scan showed cerebral regional hypometabolism in 19 patients and was normal in the other 3 patients. The distribution of abnormalities on 99mTc-HMPAO SPECT and 18F-FDG PET/CT scans was similar in 9 patients (2 SMC, 2 amnestic MCI, 2 prodromic AD, and 3 AD). In 6 patients (1 amnestic MCI, 2 prodromic AD, and 3 AD), FDG hypometabolism was more extensive than the cerebral hypoperfusion. Four patients (1 SMC, 3 amnestic MCI) had an abnormal 18F-FDG PET/CT scan and normal 99mTc-HMPAO SPECT. There were 3 patients (1 SMC, 2 amnestic MCI) with normal 99mTc-HMPAO SPECT and 18F-FDG PET/CT scans.
Conclusion
99mTc-HMPAO SPECT and 18F-FDG PET/CT scans showed cerebral hypoperfusion and hypometabolism in patients with cognitive impairment, even in patients with clinical diagnosis of SMC. In patients with a normal cerebral blood flow SPECT, brain glucose cerebral hypometabolism can be detected. In some patients, the extension of FDG hypometabolism is more pronounced than that corresponding to the hypoperfusion area.