Shuo-Han Li , Ran Guo , Ning Lv , Yu Liu , Xiaodong Tang , Jun-An Ma
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Regioselective [3 + 2] cycloaddition of diazo reagents and internal alkynes: Accessing regiosomers of highly substituted trifluoromethylpyrazoles
We herein descript a metal-free and highly regioselective [3 + 2] cycloaddition reaction between diazo compounds and internal alkynes, accessing to a series of trifluoromethylated pyrazoles. Using different combination of starting materails, both regioisomers can be obtained under this protocal. The developed cycloaddition reaction provides a valuable tool for future medicinal chemistry research on highly substituted trifluoromethyl pyrazoles.
期刊介绍：
The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature.
For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.
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