不同脊髓损伤模型基因表达谱的比较

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY Journal of Neurorestoratology Pub Date : 2023-10-14 DOI:10.1016/j.jnrt.2023.100082

Haoru Dong , Xingyu Chen , Longnian Zhou , Yiming Tao , Jian Yu , Rong Xie

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引用次数: 0

摘要

脊髓损伤(SCI)是一种毁灭性疾病，目前尚无明确的分子机制和有效的治疗方法。脊髓损伤的小鼠模型已被广泛用于探讨其发病机制。方法利用GEO数据集进行综合生物信息学分析，评价不同SCI模型的特征。结果我们发现挫伤模型与压缩模型相似，炎症和细胞凋亡明显富集，而半切和横切模型存在更复杂的生物学过程。炎症标志物不仅可以作为急性期和亚急性期脊髓损伤模型的主要评价指标，还可以作为慢性期脊髓损伤模型的主要评价指标。同时，细胞凋亡标志物更适合评价小鼠脊髓损伤模型，而炎症标志物更适合评价大鼠脊髓损伤模型。此外，还分析了不同年龄、性别、损伤部位、损伤程度的脊髓损伤模型。结论脊髓损伤是一种异质性疾病，对模型选择具有指导意义。

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Comparison on gene expression profiles between different models of spinal cord injury

Background

Spinal cord injury (SCI) is a devastating disease with no clear molecular mechanisms or effective treatments. Murine models of SCI have been widely used to explore its pathogenesis.

Methods

In this study, a comprehensive bioinformatic analysis using GEO datasets was performed to evaluate the characteristics of different SCI models.

Results

We found that the contusion model was similar to the compression model, with inflammation and apoptosis significantly enriched, while more complex biological processes existed in hemisection and transection model. Inflammatory markers can be used as a primary evaluation index of SCI models not only in the acute and subacute phases, but also in the chronic phase. In the meantime, apoptosis markers are more suitable for evaluating mouse SCI models while inflammatory markers are more suitable for rat SCI models. In addition, SCI models with different ages, genders, injury positions, and injury levels were also analyzed.