Fe2O3纳米颗粒的x射线/ γ吸收和抗癌性能

Q2 Physics and Astronomy Physics Open Pub Date : 2023-10-28 DOI:10.1016/j.physo.2023.100188

S. Deepthi , Y.S. Vidya , H.C. Manjunatha , R. Munirathnam , K.N. Sridhar , L. Seenappa , S. Manjunatha , T. Ganesh

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摘要

本研究报道了用共沉淀法合成Fe2O3纳米粒子，并对其抗癌活性进行了评价和x射线/ γ吸收研究。PXRD分析证实形成了单相三角形NPs，利用Scherrer方程和W-h图计算平均晶粒尺寸分别为45 nm和54 nm。直接能隙由Wood-Taucs图计算得到，为1.76 eV。FTIR分析证实了NPs中存在的官能团。表面形貌研究证实了SEM和EDAX分析证实了化学成分。与顺铂相比，抗癌研究证实了Fe2O3 NPs在细胞活力和细胞死亡方面的功效。最后，利用NaI(Tl)探测器评估了x射线和γ辐射屏蔽特性的质量衰减系数。屏蔽要求与铅相当。因此，合成的Fe2O3纳米颗粒可以用于抗癌活动，特别是在定制的药物输送系统中，以及辐射屏蔽代替有毒铅屏蔽。

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X-ray/gamma absorption and Anticancer Properties of Fe2O3 nanoparticles

The current study reports the synthesis of Fe $_{2}$ O $_{3}$ NPs by the co-precipitation method and the evaluation of the anticancer activity and X-ray/gamma absorption study. PXRD analysis confirmed the formation of monophase trigonal-shaped NPs, and the average crystal size is computed using both Scherrer equation and W-h plot and found to be 45 nm and 54 nm respectively. The direct energy gap is computed from the Wood-Taucs plot and found to be 1.76 eV. FTIR analysis confirmed the functional groups present in NPs. Surface morphology studies confirmed by SEM and EDAX analysis confirmed the chemical composition. Anti-cancer studies verified the efficacy of Fe $_{2}$ O $_{3}$ NPs in cell viability and cell death when compared with Cisplatin. Finally, a NaI(Tl) detector is used to evaluate Mass attenuation co-efficient of the X-ray and gamma radiation shielding characteristics. Shielding requirements are comparable to those for lead. Thus, the synthesized Fe $_{2}$ O $_{3}$ nanoparticles can be used for anticancer activities, particularly in tailored drug delivery systems, and radiation shielding instead of toxic lead shielding.