大血管闭塞性急性缺血性脑卒中血管内治疗后无效再灌注的研究进展。

IF 2.4 4区医学 Q3 CLINICAL NEUROLOGY European Neurology Pub Date : 2023-01-01 DOI:10.1159/000528922

Liyuan Wang, Yunyun Xiong

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引用次数: 2

摘要

背景:对于接受血管内治疗(EVT)的急性缺血性卒中患者来说，无效再灌注(FR)是一个迫切需要解决的问题。虽然EVT后再通率有所提高，但远未转化为组织再灌注增加和功能独立性。摘要:人们提出了许多潜在的机制，包括“无回流”现象、侧支血流不良、静脉功能障碍和炎症，但FR的病理生理机制尚不清楚。临床上，可靠的预测因素仍有待确定，正在进行的缩短时间延迟和细胞保护的试验可能为FR的干预提供新的思路。本文将总结FR的最新进展，并希望为潜在的干预措施提供线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in Futile Reperfusion following Endovascular Treatment in Acute Ischemic Stroke due to Large Vessel Occlusion.

Background: Futile reperfusion (FR) is becoming an urgent issue for acute ischemic stroke patients who underwent endovascular treatment (EVT). Although the recanalization rate has improved after EVT, it is far from translating to increased tissue reperfusion and functional independence.

Summary: Many underlying mechanisms including the "no-reflow" phenomenon, poor collateral flow, venous dysfunction, and inflammation were proposed, but the pathophysiology of FR is still unclear. Clinically, reliable predictors are still yet to be identified, and ongoing trials on shortening the time delay and cytoprotection may provide novel ideas for interventions of FR.

Key messages: This review will summarize the latest advances in FR and hopefully shed light on potential interventions.

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来源期刊

European Neurology 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： ''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.