HPCAL1是一种新的自噬依赖性铁下垂驱动因子。

IF 4.7 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Zhejiang University SCIENCE B Pub Date : 2023-11-15 DOI:10.1631/jzus.B2300241

Liwen Wang, Qin Li, Huimei Liu, Lanfang Li

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HPCAL1 is a novel driver of autophagy-dependent ferroptosis.

自噬是细胞内一种高度保守的生理过程,可通过溶酶体系统降解过量或受损的细胞器、有毒的蛋白聚集体和病原体等。最新研究表明,海马钙素样1(HPCAL1)可作为特异性自噬受体和铁死亡的正调节因子。HPCAL1可选择性降解钙粘素2(CDH2),加速脂质过氧化,促进癌细胞铁死亡。iHPCAL1是抑制HPCAL1的小分子化合物,可抑制 Erastin诱导的肿瘤细胞铁死亡。此外,它还可以抑制铁死亡诱导的急性胰腺炎。本文通过对HPCAL1在铁死亡中的具体作用机制进行概述,为HPCAL1作为铁死亡相关疾病的潜在治疗靶点提供新思路和理论依据。

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来源期刊

Journal of Zhejiang University SCIENCE B 生物-生化与分子生物学

CiteScore

8.70

自引率

13.70%

发文量

2125

审稿时长

3.0 months

期刊介绍： Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community. JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.