多形性胶质母细胞瘤治疗新出现的植物化合物研究。

Vijeta Prakash, Reema Gabrani
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摘要

尽管在多形性胶质母细胞瘤(GBM)治疗领域进行了大量研究,但对已批准治疗的耐药性仍然是一个值得关注的问题。由于克隆选择、多种发育途径的参与以及由O6-甲基鸟嘌呤DNA甲基转移酶(MGMT)介导的主要缺陷错配修复(MMR)等因素,对治疗的耐药性被广泛报道。植物疗法是克服耐药性最有效的替代方法之一。它涉及植物性化合物,分为几类:生物碱;酚类;萜烯;organosulfur化合物。这些类别中的植物化合物是从某些植物来源中提取或加工的。它们可以靶向与GBM进展和存活相关的分子途径的各种蛋白质。植物化合物也显示出作为免疫调节剂的前景,并正在探索免疫检查点抑制。因此,需要研究和创新这些植物化合物对GBM的作用机制,以开发有效的治疗方法。本文综述了基于植物化学的GBM治疗选择的潜力。
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An Insight into Emerging Phytocompounds for Glioblastoma Multiforme Therapy.

Despite intense research in the field of glioblastoma multiforme (GBM) therapeutics, the resistance against approved therapy remains an issue of concern. The resistance against the therapy is widely reported due to factors like clonal selection, involvement of multiple developmental pathways, and majorly defective mismatch repair (MMR) protein and functional O6- methylguanine DNA methyltransferase (MGMT) repair enzyme. Phytotherapy is one of the most effective alternatives to overcome resistance. It involves plant-based compounds, divided into several classes: alkaloids; phenols; terpenes; organosulfur compounds. The phytocompounds comprised in these classes are extracted or processed from certain plant sources. They can target various proteins of molecular pathways associated with the progression and survival of GBM. Phytocompounds have also shown promise as immunomodulatory agents and are being explored for immune checkpoint inhibition. Therefore, research and innovations are required to understand the mechanism of action of such phytocompounds against GBM to develop efficacious treatments for the same. This review gives insight into the potential of phytochemical-based therapeutic options for GBM treatment.

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