血栓形成与新冠肺炎感染:机制关系的最新见解。

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reviews Pub Date : 2023-01-01 DOI:10.2174/1573403X18666220512142019
Ahmed El-Medany, Vanessa Kandoole, Nicholas Lonsdale, Gemina Doolub, Ioannis Felekos
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引用次数: 0

摘要

严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)感染已被证明是诱发冠状动脉支架血栓形成的主要风险因素,因为它容易产生促血栓状态。这篇综述探讨了可能导致新冠肺炎血栓形成风险增加的机制。此外,我们还讨论了易导致支架内血栓形成风险增加的患者和血液学因素,以及某些抗血小板和抗凝疗法的作用,包括替卡格雷和依诺肝素,这些疗法可能会降低严重急性呼吸系统综合征冠状病毒2型感染中支架内血栓的可能性和严重程度。为了对抗新冠肺炎中显示的促炎和促血栓状态,未来的抗血栓治疗可能会使用血小板抑制测试和炎症调节疗法进行优化。具有长期随访的大规模随机试验对于评估新冠肺炎与支架优化的交叉点以及药物洗脱支架(DES)植入后支架血栓形成的减少越来越有必要。
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In-stent Thrombosis and COVID-19 Infection: Current Insights on the Mechanistic Relationship.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been demonstrated as a major risk factor in inducing coronary stent thrombosis due to its propensity to create a pro-thrombotic state. This review explores the mechanisms that may contribute to the increased thrombosis risk seen in COVID-19. Furthermore, we discuss the patient and haematological factors that predispose to an increased risk of stent thrombosis, as well as the role of certain antiplatelet and anticoagulation therapies, including ticagrelor and enoxaparin, that may reduce the likelihood and severity of in-stent thrombosis, in SARS-CoV-2 infection. To counter the proinflammatory and pro-thrombotic state shown in COVID-19, anti-thrombotic therapy in the future may be optimised using point-of-care platelet inhibition testing and inflammation-modifying therapies. Large-scale randomised trials with long-term follow-up are increasingly necessary to assess the intersection of COVID-19 and stent optimisation as well as the reduction of stent thrombosis after drug-eluting stent (DES) implantation.

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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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