在胰腺癌正位小鼠模型中比较分次高精度放疗的三种定位技术

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Comparative medicine Pub Date : 2022-10-01 Epub Date: 2022-09-20 DOI:10.30802/AALAS-CM-22-000060
Severin Kampfer, Sophie Dobiasch, Stephanie E Combs, Jan J Wilkens
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引用次数: 1

摘要

小动物辐照仪广泛应用于肿瘤学研究,许多实验使用小鼠来模拟人类的放射治疗。为了改进小鼠正位胰腺肿瘤的分次高精度照射,我们评估了三种定位方法:无定位辅助工具、皮肤标记和固定装置(固定面罩)。我们通过小动物放疗系统的锥形束 CT,回顾性地评估了最佳肿瘤对位(通过左右、头颅-尾椎和前后方向移动小鼠)所需的平移矢量。在这三种方法中,皮肤标记法产生的平均平移矢量最小(3.8 毫米),对大多数小鼠来说是最精确的方法。此外,皮肤标记法需要辅助旋转(即滚动、俯仰和偏航)以获得最佳肿瘤对准位置的频率仅为无助定位法的一半。最后,皮肤标记法的融合结果质量得分最高。总的来说,在胰腺癌小鼠正位模型的最佳治疗计划和放射治疗方面,我们更倾向于皮肤标记法,而不是其他两种定位方法。
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Comparison of 3 Positioning Techniques for Fractionated High-precision Radiotherapy in an Orthotopic Mouse Model of Pancreatic Cancer.

Small-animal irradiators are widely used in oncologic research, and many experiments use mice to mimic radiation treatments in humans. To improve fractionated high-precision irradiation in mice with orthotopic pancreatic tumors, we evaluated 3 positioning methods: no positioning aid, skin marker, and immobilization devices (immobilization masks). We retrospectively evaluated the translation vector needed for optimal tumor alignment (by shifting the mouse in left-right, in cranio-caudal, and in anterior-posterior direction) on cone-beam CT from our small-animal radiotherapy system. Of the 3 methods, the skin marker method yielded the smallest mean translation vector (3.8 mm) and was the most precise method overall for most of the mice. In addition, the skin marker method required supplemental rotation (that is, roll, pitch, and yaw) for optimal tumor alignment only half as often as positioning without a positioning aid. Finally, the skin marker method had the highest scores for the quality of the fusion results. Overall, we preferred the skin marker method over the other 2 positioning methods with regard to optimal treatment planning and radiotherapy in an orthotopic mouse model of pancreatic cancer.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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