1,3-二氢-1,3-二氧异吲哚衍生物的动力学、抗氧化活性、酶抑制特性及分子对接。

IF 1.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Acta Chimica Slovenica Pub Date : 2023-03-20 DOI:10.17344/acsi.2022.7808
Hasan Yakan, Seyhan Ozturk, Elvan Uyar Tolgay, Semiha Yenigun, Sarmad Marah, Tugrul Doruk, Tevfik Ozen, Halil Kutuk
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引用次数: 0

摘要

在50.0±0.1℃条件下,研究了三种不同酸对N-(对取代苯基)邻苯二胺的酸催化水解。采用DPPH•和ABTS•+清除活性两种不同的抗氧化活性试验和脲酶、乙酰胆碱酯酶(AChE)和丁基胆碱酯酶(BChE)抑制活性三种不同的酶抑制活性试验。化合物3c(2.03µg/mL)的抗氧化活性高于其他化合物,DPPH测试也符合标准。在AChE实验中,化合物3a和3b(13.13和9.59µg/mL)比标准加兰他明(14.37µg/mL)具有更高的酶抑制活性。在BChE和脲酶测试中,所有化合物(6.84 ~ 13.60µg/mL和10.49 ~ 17.73µg/mL)的酶抑制活性均高于标准加兰他明(49.40µg/mL)和硫脲(26.19µg/mL)。通过分子对接模拟,研究了这三种化合物与乙酰胆碱酯酶、乙酰胆碱酯酶和脲酶活性位点的相互作用。
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Kinetic Studies, Antioxidant Activities, Enzyme Inhibition Properties and Molecular Docking of 1,3-Dihydro-1,3-Dioxoisoindole Derivatives.

The acid catalyzed hydrolysis of the N-(p-substitutedphenyl) phthalimides in three different acids was investigated at 50.0±0.1°C. Two different antioxidant activity tests as DPPH• and ABTS•+ scavenging activities, and three various enzyme inhibition activity tests as urease, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibition activities, were applied. Compound 3c (2.03 µg/mL ) has higher antioxidant activity than other compounds and standards according to DPPH test. In AChE assay, compounds 3a and 3b (13.13 and 9.59 µg/mL) has higher enzyme inhibition activity than the standard Galantamine (14.37 µg/mL). In BChE and urease tests, all compounds (6.84-13.60 and 10.49-17.73 µg/mL) have higher enzyme inhibition activity than the standard Galantamine (49.40 µg/mL) and thiourea (26.19 µg/mL), respectively. The molecule interaction for each of the three compounds with the active sites of AChE, BChE, and urease enzymes was examined via molecular docking simulations.

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来源期刊
Acta Chimica Slovenica
Acta Chimica Slovenica 化学-化学综合
CiteScore
2.50
自引率
25.00%
发文量
80
审稿时长
1.0 months
期刊介绍: Is an international, peer-reviewed and Open Access journal. It provides a forum for the publication of original scientific research in all fields of chemistry and closely related areas. Reviews, feature, scientific and technical articles, and short communications are welcome.
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