{"title":"多油与纯豆油为基础的脂质乳剂对早产儿的临床效果:一项观察性研究。","authors":"Xing Li, Rui Zhao, Hai-Feng Lv, Miao-Fa Ying, Zhou Jiang","doi":"10.6133/apjcn.202303_32(1).0012","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>Conventional soybean oil-based intravenous lipid emulsions (SO-ILEs) have high polyunsaturated fatty acid (PUFA) contents and phytosterols that may have adverse effects in preterm infants. Recently, the multi-oil-based intravenous lipid emulsion (MO-ILE), SMOFlipid, has been widely utilized in the neonatal intensive care unit (NICU), but significant benefits over SO-ILEs in low gestational age neonates have yet to be demonstrated. This study was performed to compare the effects of the SO-ILE, Intralipid, and the MO-ILE, SMOFlipid, on neonatal health outcomes in preterm infants.</p><p><strong>Methods and study design: </strong>We performed a retrospective review of preterm infants born at gestational week (GW) <32 receiving parenteral nutrition for longer durations (≥14 d) in the NICU between 2016 and 2021. The primary aim of this study was to investigate differences in morbidity between preterm infants receiving SMOFlipid and Intralipid.</p><p><strong>Results: </strong>A total of 262 preterm infants were included in the analysis, with 126 receiving SMOFlipid and 136 receiving Intralipid. The SMOFlipid group had lower rates of ROP (23.8% vs 37.5%, respectively; p=0.017), although the rate of ROP was not different in multivariate regression analysis. The length of hospi-tal stay was significantly shorter in the SMOFlipid than SO-ILE group (median [IQR]=64.8 [37] vs 72.5 [49] days; p<0.001).</p><p><strong>Conclusions: </strong>The use of SMOFlipid as the lipid emulsion was associated with higher clinical efficacy than SO-ILE in preterm infants.</p>","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"32 1","pages":"77-84"},"PeriodicalIF":1.3000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Clinical effects of multi-oil versus pure soybean oil-based lipid emulsions for preterm infants: An observational study.\",\"authors\":\"Xing Li, Rui Zhao, Hai-Feng Lv, Miao-Fa Ying, Zhou Jiang\",\"doi\":\"10.6133/apjcn.202303_32(1).0012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>Conventional soybean oil-based intravenous lipid emulsions (SO-ILEs) have high polyunsaturated fatty acid (PUFA) contents and phytosterols that may have adverse effects in preterm infants. 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引用次数: 1
摘要
背景与目的:传统的大豆油静脉注射脂质乳剂(SO-ILEs)含有较高的多不饱和脂肪酸(PUFA)和植物甾醇,可能对早产儿产生不良影响。最近,多油基静脉注射脂质乳(MO-ILE), smof脂,已广泛应用于新生儿重症监护病房(NICU),但在低胎龄新生儿中,与SO-ILEs相比,其显著益处尚未得到证实。本研究旨在比较SO-ILE(内脂质)和MO-ILE(内脂质)对早产儿新生儿健康结局的影响。方法和研究设计:我们对妊娠周出生的早产儿(GW)进行了回顾性研究。结果:共有262例早产儿纳入分析,其中126例接受SMOFlipid治疗,136例接受Intralipid治疗。smof脂组ROP较低(分别为23.8%和37.5%);p=0.017),但在多元回归分析中ROP率无显著差异。smoffat组的住院时间明显短于SO-ILE组(中位数[IQR]=64.8 [37] vs 72.5[49]天;结论:使用smof脂作为脂乳治疗早产儿的临床疗效高于使用SO-ILE。
Clinical effects of multi-oil versus pure soybean oil-based lipid emulsions for preterm infants: An observational study.
Background and objectives: Conventional soybean oil-based intravenous lipid emulsions (SO-ILEs) have high polyunsaturated fatty acid (PUFA) contents and phytosterols that may have adverse effects in preterm infants. Recently, the multi-oil-based intravenous lipid emulsion (MO-ILE), SMOFlipid, has been widely utilized in the neonatal intensive care unit (NICU), but significant benefits over SO-ILEs in low gestational age neonates have yet to be demonstrated. This study was performed to compare the effects of the SO-ILE, Intralipid, and the MO-ILE, SMOFlipid, on neonatal health outcomes in preterm infants.
Methods and study design: We performed a retrospective review of preterm infants born at gestational week (GW) <32 receiving parenteral nutrition for longer durations (≥14 d) in the NICU between 2016 and 2021. The primary aim of this study was to investigate differences in morbidity between preterm infants receiving SMOFlipid and Intralipid.
Results: A total of 262 preterm infants were included in the analysis, with 126 receiving SMOFlipid and 136 receiving Intralipid. The SMOFlipid group had lower rates of ROP (23.8% vs 37.5%, respectively; p=0.017), although the rate of ROP was not different in multivariate regression analysis. The length of hospi-tal stay was significantly shorter in the SMOFlipid than SO-ILE group (median [IQR]=64.8 [37] vs 72.5 [49] days; p<0.001).
Conclusions: The use of SMOFlipid as the lipid emulsion was associated with higher clinical efficacy than SO-ILE in preterm infants.
期刊介绍:
The aims of the Asia Pacific Journal of Clinical Nutrition
(APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of
clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health
promotion and disease prevention. APJCN will publish
original research reports, reviews, short communications
and case reports. News, book reviews and other items will
also be included. The acceptance criteria for all papers are
the quality and originality of the research and its significance to our readership. Except where otherwise stated,
manuscripts are peer-reviewed by at least two anonymous
reviewers and the Editor. The Editorial Board reserves the
right to refuse any material for publication and advises
that authors should retain copies of submitted manuscripts
and correspondence as material cannot be returned. Final
acceptance or rejection rests with the Editorial Board