乳糜泻的免疫生物学及其发病机制。

Rasmus Iversen, Ludvig M Sollid
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引用次数: 15

摘要

在人类白细胞抗原(HLA)相关疾病中,乳糜泻的免疫发病机制已被充分了解。这种疾病的特点是对谷物麸质蛋白过敏,疾病病变局限于肠道。尽管如此,可以通过检测血液中针对谷氨酰胺转酶2的高度疾病特异性自身抗体来诊断。通过翻译后修饰的谷蛋白肽的呈现,我们现在有了关于疾病易感性HLA-DQ分子如何与这些自身抗体的产生相关联的机制见解。这篇综述介绍了我们目前对这种常见疾病的免疫生物学理解,这种疾病位于食物过敏和自身免疫之间的边界地带。
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The Immunobiology and Pathogenesis of Celiac Disease.

Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an immunopathogenesis that is particularly well understood. The condition is characterized by hypersensitivity to cereal gluten proteins, and the disease lesion is localized in the gut. Still, the diagnosis can be made by detection of highly disease-specific autoantibodies to transglutaminase 2 in the blood. We now have mechanistic insights into how the disease-predisposing HLA-DQ molecules, via presentation of posttranslationally modified gluten peptides, are connected to the generation of these autoantibodies. This review presents our current understanding of the immunobiology of this common disorder that is positioned in the border zone between food hypersensitivity and autoimmunity.

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来源期刊
CiteScore
62.60
自引率
0.00%
发文量
40
期刊介绍: The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.
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