自传体记忆动机性遗忘的神经基础。

IF 2 4区 医学 Q3 NEUROSCIENCES Cognitive Neuroscience Pub Date : 2023-01-01 DOI:10.1080/17588928.2022.2136150
FengYing Lu, WenJing Yang, Jiang Qiu
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引用次数: 3

摘要

能够控制不想要的侵入性记忆对心理健康很重要。先前的研究表明,中额叶回(MFG)下调了抑制一般记忆提取的通路。然而,自传体记忆的动机性遗忘的神经基础尚不清楚。因此,本研究采用两个样本来探讨自我参照记忆动机性遗忘的神经机制。每个参与者都提供了40个来自他们过去个人经历的生活事件(20个消极的和20个中性的),然后在接受功能磁共振成像(fMRI)的同时完成思考/不思考任务。第一个样本显示,与思考条件相比,不思考条件下的回忆明显减少。试图从意识中排除负面的自传体记忆与右侧MFG、额上回(SFG)和额下回(IFG)的活动增加有关,而双侧Brodmann区BA18和BA19、双侧内侧前额叶皮质(mPFC)、双侧楔前叶、双侧扣带回后皮质(PCC)、左侧副海马体和左侧海马体的活动减少。功能连通性分析表明,右侧MFG投射到双侧mPFC、双侧楔前叶和双侧枕中回(MOG)产生负性自传体记忆。第二个样本在行为和大脑水平上复制了第一个样本的结果。这些结果表明,自传式记忆的检索抑制涉及到MFG与mPFC和楔前叶之间的通道,以排除自我参照记忆。这些结果揭示了人们是如何在日常生活中主动遗忘负面事件的。
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Neural bases of motivated forgetting of autobiographical memories.

It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear. Therefore, this study used two samples to explore the neural mechanisms of motivated forgetting of self-referential memories. Every participant provided 40 life events (20 negative and 20 neutral) from their past personal experience, and then completed the Think/No-Think task while undergoing functional magnetic resonance imaging (fMRI). The first sample showed a significant reduction in recall in the No-Think condition relative to the Think condition. Attempting to exclude negative autobiographical memories from awareness was associated with increased activity in the right MFG, superior frontal gyrus (SFG), and inferior frontal gyrus (IFG), while reduced activity was observed in the bilateral Brodmann areas BA18 and BA19, bilateral medial prefrontal cortex (mPFC), bilateral precuneus, bilateral post cingulate cortex (PCC), the left parahippocampus, and the left hippocampus. Functional connectivity analyses showed that the right MFG projected into the bilateral mPFC, bilateral precuneus, and bilateral middle occipital gyrus (MOG) for negative autobiographical memories. The second sample replicated the results of the first sample at both the behavioral and brain levels. These results suggest that retrieval suppression of autobiographical memories involve the pathway between the MFG and the mPFC and precuneus to exclude self-referential memories. These results reveal how people engage in motivated forgetting of negative events in their daily lives.

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来源期刊
Cognitive Neuroscience
Cognitive Neuroscience NEUROSCIENCES-
CiteScore
3.60
自引率
0.00%
发文量
27
审稿时长
>12 weeks
期刊介绍: Cognitive Neuroscience publishes high quality discussion papers and empirical papers on any topic in the field of cognitive neuroscience including perception, attention, memory, language, action, social cognition, and executive function. The journal covers findings based on a variety of techniques such as fMRI, ERPs, MEG, TMS, and focal lesion studies. Contributions that employ or discuss multiple techniques to shed light on the spatial-temporal brain mechanisms underlying a cognitive process are encouraged.
期刊最新文献
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