中国儿童肠道微生物群与肥胖合并颈动脉内膜-中膜厚度高的关系

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2023-01-01 DOI:10.6133/apjcn.202303_32(1).0014
Jiahong Sun, Xuli Jin, Liu Yang, Xiaoyun Ma, Bo Xi, Suhang Song, Min Zhao
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引用次数: 0

摘要

背景和目的:儿童肥胖及相关靶器官损伤,如颈动脉内膜-中膜厚度(cIMT)增高,与以后的心血管疾病(CVD)相关。然而,肠道微生物群与儿童肥胖和高cIMT之间的关系尚不清楚。因此,我们比较了正常儿童和肥胖儿童肠道微生物群的组成、群落多样性和丰富度的差异,并结合或不具有高cIMT,以确定差异微生物群生物标志物。方法与研究设计:纳入“环台儿童心血管健康队列研究”中肥胖合并高cIMT (OB+高cIMT)儿童24例,肥胖但cIMT正常(OB+非高cIMT)儿童24例,体重正常且cIMT正常的10-11岁儿童24例,年龄和性别匹配。所有纳入的粪便样本均采用16S rRNA基因测序进行检测。结果:OB+高cIMT患儿肠道菌群群落丰富度和多样性较OB+非高cIMT患儿和正常患儿降低。在属水平上,Christensenellaceae_R-7_group、UBA1819、Family_XIII_AD3011_group和unclassi_fied_o_bacteroidales的相对丰度与儿童OB+高cimt的发生率降低相关。受试者工作特征(ROC)分析显示,Christensenellaceae_R-7_group、UBA1819、family - ly_xiii_ad3011_group和unclassified_o_Bacteroidales组合对OB+高cimt具有较高的识别能力。群落系统发育研究(PICRUSt)显示,OB+高cimt组氨基酸生物合成和氨基酰基- trna途径等多条通路低于正常组。结论:我们发现肠道菌群的改变与儿童OB+高cimt相关,这表明肠道菌群可能是儿童肥胖和相关心血管损伤的标志。
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Association between gut microbiota and obesity combined with high carotid intima-media thickness among Chinese children.

Background and objectives: Obesity and related target organ damage such as high carotid intima-media thickness (cIMT) in children is associated with cardiovascular disease (CVD) later in life. However, the asso-ciation between gut microbiota and obesity combined with high cIMT among children remains unclear. Therefore, we compared differences in composition, community diversity, and richness of gut microbiota among normal children and obesity combined with or without high cIMT to identify differential microbiota biomarkers.

Methods and study design: A total of 24 children with obesity combined with high cIMT (OB+high-cIMT), 24 with obesity but normal cIMT (OB+non-high cIMT), and 24 with normal weight and normal cIMT aged 10-11 years matched by age and sex from the "Huantai Childhood Cardiovascular Health Cohort Study" were included. All included fecal samples were tested using 16S rRNA gene sequencing.

Results: The community richness and diversity of gut microbiota in OB+high-cIMT children were decreased compared with OB+non-high cIMT children and normal children. At the genus level, the relative abundances of Christensenellaceae_R-7_group, UBA1819, Family_XIII_AD3011_group, and unclassi-fied_o_Bacteroidales were associated with reduced odds of OB+high-cIMT among children. Receiver operating characteristic (ROC) analysis showed that combined Christensenellaceae_R-7_group, UBA1819, Fami-ly_XIII_AD3011_group, and unclassified_o_Bacteroidales performed a high ability in identifying OB+high-cIMT. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) showed that several pathways such as biosynthesis of amino acids and aminoacyl-tRNA pathways were lower in the OB+high-cIMT group compared with the normal group.

Conclusions: We found that the alteration of gut microbiota was associated with OB+high-cIMT among children, which indicates that the gut microbiota may be a marker for obesity and related cardiovascular damage among children.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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