Negar Karimi, Hesam Aldin Seifi, Mohammad Heidarpour
{"title":"奶牛早期干燥期和过渡期全血重金属与血清免疫和氧化标记物的相关性。","authors":"Negar Karimi, Hesam Aldin Seifi, Mohammad Heidarpour","doi":"10.1017/S0022029923000055","DOIUrl":null,"url":null,"abstract":"<p><p>Immunological and oxidative alterations have been reported around calving in dairy cattle. In addition, the levels of heavy metals rise in the blood around parturition, which might affect body systems. Therefore, in this Research Communication we evaluate the changes in whole blood lead (Pb), arsenic (As), and cadmium (Cd) around calving, in comparison with the beginning of the dry period, and assess the correlations of these elements with immunological factors and oxidative markers. Samples were collected from 30 clinically healthy dairy cows in the early dry period (-6 w), one week before expected calving (-1 w), and one week postpartum (+1 w). The highest concentrations of Pb, As, and Cd were observed at -1 w and all the three elements decreased after parturition leading to significantly lower As and Cd, compared to -1 w (<i>P <</i> 0.05). The lowest levels of tumor necrosis factor-alpha, immunoglobulin G, interleukin 4, interleukin 10 and haptoglobin were found at -1 w simultaneous with the highest measures of the heavy metals, with tumor necrosis factor-alpha being significantly lower at this time (<i>P <</i> 0.05). At -6 w, As concentration was significantly (<i>P <</i> 0.05) correlated negatively (<i>r</i> = -0.366) and positively (<i>r</i> = 0.417) with total antioxidant capacity and malondialdehyde, respectively. Furthermore, at -1 w Pb and As had significant (<i>P <</i> 0.05) negative correlations with interferon gamma (<i>r</i> = -0.502) and interleukin 4 (<i>r</i> = -0.483), respectively. After parturition, Pb was observed to be negatively correlated with total antioxidant capacity (<i>r</i> = -0.538, <i>P <</i> 0.05). The observed results revealed that the alterations in immunological factors and antioxidant capacity around parturition were correlated with Pb and As levels.</p>","PeriodicalId":15615,"journal":{"name":"Journal of Dairy Research","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlations of whole blood heavy metals with serum immunological and oxidative markers during the early dry period and transition period of dairy cattle.\",\"authors\":\"Negar Karimi, Hesam Aldin Seifi, Mohammad Heidarpour\",\"doi\":\"10.1017/S0022029923000055\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Immunological and oxidative alterations have been reported around calving in dairy cattle. In addition, the levels of heavy metals rise in the blood around parturition, which might affect body systems. Therefore, in this Research Communication we evaluate the changes in whole blood lead (Pb), arsenic (As), and cadmium (Cd) around calving, in comparison with the beginning of the dry period, and assess the correlations of these elements with immunological factors and oxidative markers. Samples were collected from 30 clinically healthy dairy cows in the early dry period (-6 w), one week before expected calving (-1 w), and one week postpartum (+1 w). The highest concentrations of Pb, As, and Cd were observed at -1 w and all the three elements decreased after parturition leading to significantly lower As and Cd, compared to -1 w (<i>P <</i> 0.05). The lowest levels of tumor necrosis factor-alpha, immunoglobulin G, interleukin 4, interleukin 10 and haptoglobin were found at -1 w simultaneous with the highest measures of the heavy metals, with tumor necrosis factor-alpha being significantly lower at this time (<i>P <</i> 0.05). At -6 w, As concentration was significantly (<i>P <</i> 0.05) correlated negatively (<i>r</i> = -0.366) and positively (<i>r</i> = 0.417) with total antioxidant capacity and malondialdehyde, respectively. Furthermore, at -1 w Pb and As had significant (<i>P <</i> 0.05) negative correlations with interferon gamma (<i>r</i> = -0.502) and interleukin 4 (<i>r</i> = -0.483), respectively. After parturition, Pb was observed to be negatively correlated with total antioxidant capacity (<i>r</i> = -0.538, <i>P <</i> 0.05). The observed results revealed that the alterations in immunological factors and antioxidant capacity around parturition were correlated with Pb and As levels.</p>\",\"PeriodicalId\":15615,\"journal\":{\"name\":\"Journal of Dairy Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Dairy Research\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1017/S0022029923000055\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dairy Research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1017/S0022029923000055","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
Correlations of whole blood heavy metals with serum immunological and oxidative markers during the early dry period and transition period of dairy cattle.
Immunological and oxidative alterations have been reported around calving in dairy cattle. In addition, the levels of heavy metals rise in the blood around parturition, which might affect body systems. Therefore, in this Research Communication we evaluate the changes in whole blood lead (Pb), arsenic (As), and cadmium (Cd) around calving, in comparison with the beginning of the dry period, and assess the correlations of these elements with immunological factors and oxidative markers. Samples were collected from 30 clinically healthy dairy cows in the early dry period (-6 w), one week before expected calving (-1 w), and one week postpartum (+1 w). The highest concentrations of Pb, As, and Cd were observed at -1 w and all the three elements decreased after parturition leading to significantly lower As and Cd, compared to -1 w (P < 0.05). The lowest levels of tumor necrosis factor-alpha, immunoglobulin G, interleukin 4, interleukin 10 and haptoglobin were found at -1 w simultaneous with the highest measures of the heavy metals, with tumor necrosis factor-alpha being significantly lower at this time (P < 0.05). At -6 w, As concentration was significantly (P < 0.05) correlated negatively (r = -0.366) and positively (r = 0.417) with total antioxidant capacity and malondialdehyde, respectively. Furthermore, at -1 w Pb and As had significant (P < 0.05) negative correlations with interferon gamma (r = -0.502) and interleukin 4 (r = -0.483), respectively. After parturition, Pb was observed to be negatively correlated with total antioxidant capacity (r = -0.538, P < 0.05). The observed results revealed that the alterations in immunological factors and antioxidant capacity around parturition were correlated with Pb and As levels.
期刊介绍:
The Journal of Dairy Research is an international Journal of high-standing that publishes original scientific research on all aspects of the biology, wellbeing and technology of lactating animals and the foods they produce. The Journal’s ability to cover the entire dairy foods chain is a major strength. Cross-disciplinary research is particularly welcomed, as is comparative lactation research in different dairy and non-dairy species and research dealing with consumer health aspects of dairy products. Journal of Dairy Research: an international Journal of the lactation sciences.