NLPR3炎性小体增加神经炎症加速抑郁样行为

IF 2 4区医学 Q3 CLINICAL NEUROLOGY Current neurovascular research Pub Date : 2022-01-01 DOI:10.2174/1567202619666220829110111

Jie Liu, Enyan Yu

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引用次数: 1

摘要

抑郁症是一类重要的精神疾病，因其高发病率、高致残率和巨大的疾病负担，已成为困扰世界的严重健康问题。本研究旨在评估P2RY12在抑郁样行为模型中的作用及其可能机制。方法:采用抑郁样行为患者血清样本分析P2RY12的表达。小鼠模型腹腔注射LPS 7 d。在这个实验中进行了行为测试。结果:诱导P2RY12在抑郁样行为模型或抑郁样行为小鼠中的表达。抑制P2RY12在抑郁样行为模型中表现出抑郁样行为并减轻炎症。在抑郁样行为模型中，P2RY12诱导NLRP3表达并抑制NLRP3泛素化。抑制NLRP3可降低P2RY12在小鼠抑郁样行为模型中的作用。NLRP3调控P2RY12在体外抑郁样行为模型中的作用。结论:P2RY12通过NLPR3炎性小体增加神经炎症从而加速抑郁样行为，为治疗抑郁样行为提供了新的信息。

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P2RY12 Increased Neuroinflammation to Accelerate Depression-like Behaviors by the NLPR3 Inflammasome.

Introduction: Depression is a class of important mental illness, which has become a severe health problem perplexing the world due to its high morbidity rate, high disability rate, and great disease burden. This study aimed to evaluate the role and possible mechanisms of P2RY12 in the depression-like behaviors model.

Methods: Serum samples of patients with depression-like behaviors were used to analyze the expression of P2RY12. Models of mice were given LPS via intraperitoneal injection for 7 days. Behavioral tests were executed in this experiment.

Results: The expression of P2RY12 in models of depression-like behaviors or mice with depression- like behaviors were induced. The inhibition of P2RY12 presents depression-like behaviors and reduces inflammation in the model of depression-like behaviors. P2RY12 induced NLRP3 expression and suppressed NLRP3 ubiquitination in a model of depression-like behavior. The inhibition of NLRP3 reduced the effects of P2RY12 in mice model of depression-like behaviors. The regulation of NLRP3 controlled the effects of the P2RY12 in vitro model of depression-like behaviors.

Conclusion: We conclude that P2RY12 increased neuroinflammation to accelerate depression-like behaviors by NLPR3 inflammasome, providing novel information for the treatment of depressionlike behaviors.

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来源期刊

Current neurovascular research 医学-临床神经学

CiteScore

3.80

自引率

9.50%

发文量

审稿时长

3 months

期刊介绍： Current Neurovascular Research provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum publishing novel and original work as well as timely neuroscience research articles, full-length/mini reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridges the gap between basic science research and clinical discovery. Current Neurovascular Research emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.