糖皮质激素选择性影响接种疫苗和感染后系统性红斑狼疮患者对SARS-Cov2尖峰的记忆T细胞反应

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2023-01-01 DOI:10.1016/j.jtauto.2023.100200
Yves Renaudineau , Chloé Bost , Florence Abravanel , Jacques Izopet , Antoine Blancher , Nicolas Congy , Emmanuel Treiner , Laurent Sailler
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摘要

系统性红斑狼疮(SLE)患者对疫苗和病原体的免疫反应尚不清楚。为了对此进行调查,对47名接种新冠肺炎疫苗的SLE患者进行了单中心回顾性研究,其中13人随后出现无症状/轻度疾病。与对照组相比,当考虑全血干扰素γ释放试验(IGRA-S)中的记忆T细胞和IgG抗Spike抗体(Ab)反应时,SLE患者的疫苗接种后对Spike的反应降低。SLE相关的缺陷IGRA-S反应与低于40g/L的血清白蛋白水平和糖皮质激素的使用有关,而缺陷IgG抗Spike Ab反应与较低水平的抗dsDNA和抗SSA/Ro 52kDa Abs有关。IGRA-S和IgG抗尖峰反应独立于SLE活动和临床表型、低补体、高丙种球蛋白血症和淋巴细胞减少症。与对照组相比,SLE患者表现出抗刺突T细胞记忆的快速衰退和稳定的IgG抗刺突抗体反应。总之,在我们的SLE患者队列中,T细胞和体液抗尖峰反应都受到独立影响,这支持在SLE患者的随访中,特别是在接受糖皮质激素治疗的患者中,探索这两种反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Glucocorticoids selectively affect the memory T cell response to SARS-Cov2 spike in vaccinated and post-infected patients with systemic lupus erythematosus

Immune response to vaccines and pathogens remains unclear in patients with systemic lupus erythematosus (SLE). To investigate this, a single-center retrospective study was conducted with 47 SLE patients vaccinated against COVID-19, including 13 who subsequently developed an asymptomatic/mild disease. As compared to controls, post-vaccine response against Spike was reduced in SLE patients when considering both memory T-cells in a whole blood interferon gamma release assay (IGRA-S) and IgG anti-Spike antibody (Ab) responses. The SLE-associated defective IGRA-S response was associated with a serum albumin level below 40 g/L and with the use of glucocorticoids, while a defective IgG anti-Spike Ab response was associated with lower levels of anti-dsDNA and anti-SSA/Ro 52 kDa Abs. IGRA-S and IgG anti-Spike responses were independent from SLE activity and clinical phenotype, low complement, hypergammaglobulinemia, and lymphopenia. As compared to controls, SLE patients showed a rapid decay of anti-Spike T-cell memory and stable IgG anti-Spike Ab responses. In conclusion, both T cell and humoral anti-Spike responses were independently affected in our SLE patients cohort, which supports the exploration of both responses in the follow-up of SLE patients and especially in those receiving glucocorticoids.

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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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