{"title":"半月板疾病中的微RNA:当前概念。","authors":"Filippo Migliorini, Gianluca Vecchio, Riccardo Giorgino, Jörg Eschweiler, Frank Hildebrand, Nicola Maffulli","doi":"10.1093/bmb/ldac039","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Micro RNAs (miRNAs) are short non-coding RNAs that act primarily in posttranscriptional gene silencing, and are attracting increasing interest in musculoskeletal conditions.</p><p><strong>Source of data: </strong>Current scientific literature published in PubMed, Google Scholar, Embase and Web of Science databases.</p><p><strong>Areas of agreement: </strong>Recently, the potential of miRNAs as biomarkers for diagnosis and treatment of meniscal injuries has been postulated.</p><p><strong>Areas of controversy: </strong>Evaluation of the role of miRNAs in patients with meniscal tears is still controversial.</p><p><strong>Growing points: </strong>A systematic review was conducted to investigate the potential of miRNA in the diagnosis and management of meniscal damage.</p><p><strong>Areas timely for developing research: </strong>Intra-articular injection of microRNA-210 in vivo may represent a potential innovative methodology for the management of meniscal injuries. Characterization of the miRNAs expression in the synovial fluid could lead to the development of better early diagnosis and management strategies for meniscal tears.</p>","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":"145 1","pages":"141-150"},"PeriodicalIF":6.7000,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Micro RNA in meniscal ailments: current concepts.\",\"authors\":\"Filippo Migliorini, Gianluca Vecchio, Riccardo Giorgino, Jörg Eschweiler, Frank Hildebrand, Nicola Maffulli\",\"doi\":\"10.1093/bmb/ldac039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Micro RNAs (miRNAs) are short non-coding RNAs that act primarily in posttranscriptional gene silencing, and are attracting increasing interest in musculoskeletal conditions.</p><p><strong>Source of data: </strong>Current scientific literature published in PubMed, Google Scholar, Embase and Web of Science databases.</p><p><strong>Areas of agreement: </strong>Recently, the potential of miRNAs as biomarkers for diagnosis and treatment of meniscal injuries has been postulated.</p><p><strong>Areas of controversy: </strong>Evaluation of the role of miRNAs in patients with meniscal tears is still controversial.</p><p><strong>Growing points: </strong>A systematic review was conducted to investigate the potential of miRNA in the diagnosis and management of meniscal damage.</p><p><strong>Areas timely for developing research: </strong>Intra-articular injection of microRNA-210 in vivo may represent a potential innovative methodology for the management of meniscal injuries. Characterization of the miRNAs expression in the synovial fluid could lead to the development of better early diagnosis and management strategies for meniscal tears.</p>\",\"PeriodicalId\":9280,\"journal\":{\"name\":\"British medical bulletin\",\"volume\":\"145 1\",\"pages\":\"141-150\"},\"PeriodicalIF\":6.7000,\"publicationDate\":\"2023-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British medical bulletin\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/bmb/ldac039\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British medical bulletin","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/bmb/ldac039","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 3
摘要
微rna (miRNAs)是一种短的非编码rna，主要在转录后基因沉默中起作用，并且在肌肉骨骼疾病中引起了越来越多的兴趣。数据来源:在PubMed、Google Scholar、Embase和Web of Science数据库中发表的最新科学文献。共识领域:最近，mirna作为半月板损伤诊断和治疗的生物标志物的潜力已经被假设。争议领域:评估mirna在半月板撕裂患者中的作用仍然存在争议。成长要点:系统回顾了miRNA在半月板损伤诊断和治疗中的潜力。及时开展研究的领域:在体内关节内注射microRNA-210可能是治疗半月板损伤的潜在创新方法。表征滑膜液中miRNAs的表达可能会导致半月板撕裂的更好的早期诊断和管理策略的发展。
Introduction: Micro RNAs (miRNAs) are short non-coding RNAs that act primarily in posttranscriptional gene silencing, and are attracting increasing interest in musculoskeletal conditions.
Source of data: Current scientific literature published in PubMed, Google Scholar, Embase and Web of Science databases.
Areas of agreement: Recently, the potential of miRNAs as biomarkers for diagnosis and treatment of meniscal injuries has been postulated.
Areas of controversy: Evaluation of the role of miRNAs in patients with meniscal tears is still controversial.
Growing points: A systematic review was conducted to investigate the potential of miRNA in the diagnosis and management of meniscal damage.
Areas timely for developing research: Intra-articular injection of microRNA-210 in vivo may represent a potential innovative methodology for the management of meniscal injuries. Characterization of the miRNAs expression in the synovial fluid could lead to the development of better early diagnosis and management strategies for meniscal tears.
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British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries.
Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.
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