12周最大脂肪氧化强度(FATmax)运动对肥胖非酒精性脂肪肝患者微血管功能的影响及其机制

IF 1.3 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY General physiology and biophysics Pub Date : 2023-05-01 DOI:10.4149/gpb_2023004
Ruiqi Yang, Li Wan, Huan Zhu, Yong Peng
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引用次数: 1

摘要

本研究选择54例非酒精性脂肪性肝病(NAFLD)肥胖患者,随机分为运动组(男性16例,女性11例,平均年龄21.3±1.0岁)和对照组(男性16例,女性11例,平均年龄21.8±0.8岁)。运动组进行了为期12周的FATmax运动干预,而对照组没有进行任何类型的系统体育活动。两组都接受了控制饮食。试验后,运动组微血管反应性显著高于对照组(p < 0.05)。实验结束后,运动组丙二醛(MDA)浓度、过氧化氢酶(CAT)活性和运动组活性均显著低于对照组(p < 0.05);总超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性显著高于对照组(p< 0.05)。12周的FATmax强度运动引起的微循环功能改变可能与氧化应激和抗氧化系统功能存在交互作用机制,并可能改善肥胖NAFLD患者微血管反应性。此外,还可改善氧化应激和抗氧化系统功能。
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The effect of 12 week-maximum fat oxidation intensity (FATmax) exercise on microvascular function in obese patients with nonalcoholic fatty liver disease and its mechanism.

Fifty-four obese patients with non-alcoholic fatty liver disease (NAFLD) were selected for this study were randomly divided into an exercise group (16 men and 11 women, mean age 21.3 ± 1.0) and control group (16 men and 11 women, mean age 21.8 ± 0.8). The exercise group underwent a 12-week FATmax exercise intervention, while the control group did not engage in any type of systematic physical activity. The controlled diet was given to both groups. After the test, the microvascular reactivity of the exercise group was significantly higher than that of the control group (p < 0.05). After the experiment, the concentration of malondialdehyde (MDA), the activity of catalase (CAT) and the activity of exercise group were significantly lower than those of the control group (p < 0.05); and in contrast the activities of total superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were significantly higher than those of the control group (p< 0.05). The change in microcirculation function caused by 12-week FATmax intensity exercise may have an interaction mechanism with oxidative stress and antioxidant system function, and may improve the microvascular reactivity of obese NAFLD patients. In addition, also may improve of oxidative stress and antioxidant system functions.

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来源期刊
General physiology and biophysics
General physiology and biophysics 生物-生化与分子生物学
CiteScore
2.70
自引率
0.00%
发文量
42
审稿时长
6-12 weeks
期刊介绍: General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.
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