幼崽第一次社交经历中听到的声音增加了小鼠听觉皮层的Bdnf转录。

IF 3 4区 医学 Q2 NEUROSCIENCES Neural Plasticity Pub Date : 2023-01-01 DOI:10.1155/2023/5225952
Amielle Moreno, Swetha Rajagopalan, Matthew J Tucker, Parker Lunsford, Robert C Liu
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引用次数: 0

摘要

虽然婴儿线索通常被认为是天生激发母亲的反应,但最近的研究强调了婴儿线索的神经编码是如何通过母亲的照顾而改变的。婴儿发声是照顾者重要的社会信号,来自小鼠的证据表明,照顾幼鼠的经历会诱发听觉皮层(AC)的抑制性可塑性,尽管在幼鼠最初经历中这种AC可塑性的分子介质尚未得到很好的描述。在这里,我们使用母鼠通信模型来探索在控制激素雌激素的全身影响的同时,在第一次幼鼠护理经历中,一种特定的,抑制相关的,记忆相关的基因,脑源性神经营养因子(Bdnf)的AC转录是否会因听到叫声而发生变化。卵巢切除、雌二醇或空白植入的雌性雌性小鼠在听到幼崽叫声时,其AC外显子IV Bdnf mRNA显著高于没有幼崽的雌性小鼠,这表明发声的社会背景在听觉皮层加工部位引起了即时的分子变化。E2影响了母性行为的比率,但没有显著影响AC中Bdnf mRNA的转录。据我们所知,这是Bdnf第一次与AC中社会发声的加工有关,我们的结果表明,它是一个潜在的分子成分,负责通过促进AC可塑性来增强未来对婴儿线索的识别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex.

While infant cues are often assumed to innately motivate maternal response, recent research highlights how the neural coding of infant cues is altered through maternal care. Infant vocalizations are important social signals for caregivers, and evidence from mice suggests that experience caring for mouse pups induces inhibitory plasticity in the auditory cortex (AC), though the molecular mediators for such AC plasticity during the initial pup experience are not well delineated. Here, we used the maternal mouse communication model to explore whether transcription in AC of a specific, inhibition-linked, memory-associated gene, brain-derived neurotrophic factor (Bdnf) changes due to the very first pup caring experience hearing vocalizations, while controlling for the systemic influence of the hormone estrogen. Ovariectomized and estradiol or blank-implanted virgin female mice hearing pup calls with pups present had significantly higher AC exon IV Bdnf mRNA compared to females without pups present, suggesting that the social context of vocalizations induces immediate molecular changes at the site of auditory cortical processing. E2 influenced the rate of maternal behavior but did not significantly affect Bdnf mRNA transcription in the AC. To our knowledge, this is the first time Bdnf has been associated with processing social vocalizations in the AC, and our results suggest that it is a potential molecular component responsible for enhancing future recognition of infant cues by contributing to AC plasticity.

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来源期刊
Neural Plasticity
Neural Plasticity NEUROSCIENCES-
CiteScore
6.80
自引率
0.00%
发文量
77
审稿时长
16 weeks
期刊介绍: Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.
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