BDNF：创伤性脑损伤中老角色的新观点。

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY Neuroscientist Pub Date : 2024-10-01 Epub Date: 2023-04-17 DOI:10.1177/10738584231164918

Lauren P Giesler, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald

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引用次数: 0

摘要

脑外伤是一种常见的健康问题，每年影响数百万人。由于 BDNF 在维持脑平衡中的关键作用，人们一直在研究脑外伤中的 BDNF。Val66Met 是一种功能性单核苷酸多态性，会导致 BDNF 原域中第 66 个密码子上的氨基酸发生缬氨酸到蛋氨酸的置换，最终减少 BDNF 的分泌。在此，我们回顾了有关 Val66Met 单核苷酸多态性在创伤性脑损伤结果（包括认知功能、运动功能、神经精神症状和痛觉）中作用的实验动物模型和临床研究。我们还回顾了有关 BDNF 对创伤性脑损伤病理生理学作用的研究，以及作为创伤性脑损伤生物标志物的循环 BDNF。

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BDNF: New Views of an Old Player in Traumatic Brain Injury.

Traumatic brain injury is a common health problem affecting millions of people each year. BDNF has been investigated in the context of traumatic brain injury due to its crucial role in maintaining brain homeostasis. Val66Met is a functional single-nucleotide polymorphism that results in a valine-to-methionine amino acid substitution at codon 66 in the BDNF prodomain, which ultimately reduces secretion of BDNF. Here, we review experimental animal models as well as clinical studies investigating the role of the Val66Met single-nucleotide polymorphism in traumatic brain injury outcomes, including cognitive function, motor function, neuropsychiatric symptoms, and nociception. We also review studies investigating the role of BDNF on traumatic brain injury pathophysiology as well as circulating BDNF as a biomarker of traumatic brain injury.

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来源期刊

Neuroscientist 医学-临床神经学

CiteScore

11.50

自引率

0.00%

发文量

期刊介绍： Edited by Stephen G. Waxman, The Neuroscientist (NRO) reviews and evaluates the noteworthy advances and key trends in molecular, cellular, developmental, behavioral systems, and cognitive neuroscience in a unique disease-relevant format. Aimed at basic neuroscientists, neurologists, neurosurgeons, and psychiatrists in research, academic, and clinical settings, The Neuroscientist reviews and updates the most important new and emerging basic and clinical neuroscience research.

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