作为抗菌、消炎和抗氧化剂的新型三唑烷-2-硫酮类似物的合成、QSAR 研究和药理评估。

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS Combinatorial chemistry & high throughput screening Pub Date : 2025-01-13 DOI:10.2174/1386207326666230302101657
Abhishek Sharma, Rubina Bhutani, Akanksha Gupta, Manni Dutta
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引用次数: 0

摘要

背景:三唑类似物因其广泛的药理应用而具有巨大的吸引力:本研究涉及三唑-2-硫酮类似物的合成及其 QSAR 研究。方法:本研究涉及三唑-2-硫酮类似物的合成及其 QSAR 研究,还评估了合成的类似物的抗菌、抗炎和抗氧化作用:结果表明,苯甲酰胺类似物(3a、3d)和三唑烷类似物(4b)对铜绿假单胞菌和大肠杆菌的活性最强,pMIC 值分别为 1.69、1.69 和 1.72。衍生物的抗氧化研究表明,4b 是最有效的抗氧化剂,蛋白质变性抑制率为 79%。3f、4a 和 4f 的抗炎活性最高:本研究为进一步开发更多潜在的抗炎、抗氧化和抗菌剂提供了一些有力的线索。
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WITHDRAWN: Synthesis, QSAR Study and Pharmacological Evaluation of Novel Triazolidine-2-thione Analogues as Antimicrobial, Antiinflammatory and Antioxidant Agents

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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来源期刊
CiteScore
3.10
自引率
5.60%
发文量
327
审稿时长
7.5 months
期刊介绍: Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.
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