决明子抗衰老相关疾病的临床前研究。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-10-25 DOI:10.1017/erm.2022.33
Sun-Young Hwang, Chang-Su Na, Byeong Cheol Moon, Jung-Hyun Shim, Mee-Hyun Lee
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引用次数: 0

摘要

在全球范围内,人口老龄化日益加剧,老龄化是一种自然的生理过程,也是所有与年龄有关的疾病的主要危险因素。它严重威胁个人健康,并造成巨大的经济负担。因此,越来越多的科学兴趣是如何预防和治疗与年龄有关的疾病。决明子决明子的种子、根、茎或叶在体内体外均具有抗炎、抗氧化等药理作用,具有抗菌、抗高脂血症、抗肥胖等作用。然而,到目前为止,还没有临床试验的尝试,因此,我们想了解目前的衰老相关疾病模型的临床前活动,包括白内障,代谢功能障碍和神经退行性变,然后讨论他们的临床试验准备和观点。
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Preclinical activities of Cassia tora Linn against aging-related diseases.

Globally, an aging population is increasing, and aging is a natural physiological process and a major risk factor for all age-related diseases. It seriously threatens personal health and imposes a great economic burden. Therefore, there is a growing scientific interest in strategies for well-aging with prevention and treatment of age-related diseases. The seed, root, stem or leaves of Cassia tora Linn. are useful for anti-bacteria, anti-hyperlipidemia and anti-obesity due to its pharmacological activities such as anti-inflammation and anti-oxidant both in vitro and in vivo. Nevertheless, no clinical trials have been attempted so far, therefore here we would like to understand the current preclinical activities for aging-related disease models including cataract, metabolic dysfunction and neurodegeneration, then discuss their preparation for clinical trials and perspectives.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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