IgE、IgE 受体和抗 IgE 生物制剂:蛋白质结构和作用机制。

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2023-04-26 Epub Date: 2023-02-03 DOI:10.1146/annurev-immunol-061020-053712
J M McDonnell, B Dhaliwal, B J Sutton, H J Gould
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引用次数: 0

摘要

哺乳动物 IgE 的进化为体表增加了一层额外的免疫保护层,对来自环境的抗原做出快速的局部反应。IgE 免疫反应对局部抗原刺激具有强大的驱逐和炎症作用,但有可能损害宿主组织并导致过敏性疾病。两种众所周知的 IgE 受体,即高亲和力的 FcεRI 和低亲和力的 CD23,介导着 IgE 的活动。与其他已知的抗体受体不同,CD23 还能调节 IgE 的表达,维持 IgE 的平衡。这一机制是通过调整补体受体 CD21 的功能演变而来的。最近,人们对 IgE 结构的动态特性、由此产生的异位调节能力以及配体诱导解离的潜力有了深入的了解,这揭示了以前未被重视的 IgE 和 IgE 复合物的调节机制。我们将介绍近期的研究,重点介绍 IgE 蛋白网络的结构研究,以分析 IgE 和抗 IgE 生物制剂独特的多功能活性。
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IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action.

The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the environment. The IgE immune response employs potent expulsive and inflammatory forces against local antigen provocation, at the risk of damaging host tissues and causing allergic disease. Two well-known IgE receptors, the high-affinity FcεRI and low-affinity CD23, mediate the activities of IgE. Unlike other known antibody receptors, CD23 also regulates IgE expression, maintaining IgE homeostasis. This mechanism evolved by adapting the function of the complement receptor CD21. Recent insights into the dynamic character of IgE structure, its resultant capacity for allosteric modulation, and the potential for ligand-induced dissociation have revealed previously unappreciated mechanisms for regulation of IgE and IgE complexes. We describe recent research, highlighting structural studies of the IgE network of proteins to analyze the uniquely versatile activities of IgE and anti-IgE biologics.

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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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