Anita Lynam, Charlotte Curtis, Brooklyn Stanley, Heath Heatley, Chloe Worthington, Emma-Jane Roberts, Christopher Price, Victoria Carter, John Dennis, Andrew McGovern, David Price
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引用次数: 1
摘要
简介:电子医疗记录(EMR)维护在英国的初级保健和收集和存储在EMR数据库提供了一个世界领先的资源，观察性临床研究。我们的目标是分析一个这样的数据库:最佳患者护理研究数据库(OPCRD)。方法和参与者:OPCRD成立于2010年，是一个不断发展的初级保健电子病历数据库，收集了英国992个全科医生的数据。它覆盖了英国所有四个国家的1660多万患者，在年龄、性别、种族和社会经济地位方面广泛代表了英国人口。患者的平均随访时间为11.7年(SD 17.50)，大多数患者拥有从出生到最后一次数据录入的关键汇总数据。OPCRD的数据每月递增收集，并从英国使用的所有主要临床软件系统和所有四种编码系统(Read version 2, Read CTV3, SNOMED DM+D和SNOMED CT代码)中提取。通过向全科医生诊所提供质量改进方案，OPCRD还纳入了一系列针对特定疾病的有效问卷中患者报告的结果，其中包括6.6万多名患者对哮喘、慢性阻塞性肺病和COVID-19的答复。此外，通过与全科医生合作，通过患者报告的问卷收集新的研究，可以定制数据收集。自成立以来，OPCRD已发表了96份同行评议的研究出版物，涉及包括COVID-19在内的广泛医疗状况。结论:OPCRD代表了一种独特的资源，具有支持流行病学研究的巨大潜力，从回顾性观察性研究到嵌入式集群随机试验。与其他电子病历数据库相比，OPCRD的优势在于其庞大的规模、全英国的地理覆盖范围、所有主要全科医生软件系统的最新患者数据的可用性，以及患者报告的呼吸健康信息的独特收集。
Data-Resource Profile: United Kingdom Optimum Patient Care Research Database.
Introduction: Electronic medical records (EMRs) maintained in primary care in the UK and collected and stored in EMR databases offer a world-leading resource for observational clinical research. We aimed to profile one such database: the Optimum Patient Care Research Database (OPCRD).
Methods and participants: The OPCRD, incepted in 2010, is a growing primary care EMR database collecting data from 992 general practices within the UK. It covers over 16.6 million patients across all four countries within the UK, and is broadly representative of the UK population in terms of age, sex, ethnicity and socio-economic status. Patients have a mean duration of 11.7 years' follow-up (SD 17.50), with a majority having key summary data from birth to last data entry. Data for the OPCRD are collected incrementally monthly and extracted from all of the major clinical software systems used within the UK and across all four coding systems (Read version 2, Read CTV3, SNOMED DM+D and SNOMED CT codes). Via quality-improvement programmes provided to GP surgeries, the OPCRD also includes patient-reported outcomes from a range of disease-specific validated questionnaires, with over 66,000 patient responses on asthma, COPD, and COVID-19. Further, bespoke data collection is possible by working with GPs to collect new research via patient-reported questionnaires.
Findings to date: The OPCRD has contributed to over 96 peer-reviewed research publications since its inception encompassing a broad range of medical conditions, including COVID-19.
Conclusion: The OPCRD represents a unique resource with great potential to support epidemiological research, from retrospective observational studies through to embedded cluster-randomised trials. Advantages of the OPCRD over other EMR databases are its large size, UK-wide geographical coverage, the availability of up-to-date patient data from all major GP software systems, and the unique collection of patient-reported information on respiratory health.
期刊介绍：
Pragmatic and Observational Research is an international, peer-reviewed, open-access journal that publishes data from studies designed to closely reflect medical interventions in real-world clinical practice, providing insights beyond classical randomized controlled trials (RCTs). While RCTs maximize internal validity for cause-and-effect relationships, they often represent only specific patient groups. This journal aims to complement such studies by providing data that better mirrors real-world patients and the usage of medicines, thus informing guidelines and enhancing the applicability of research findings across diverse patient populations encountered in everyday clinical practice.
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