HIV患者的盐味和盐敏感性高血压。

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Current Hypertension Reports Pub Date : 2023-03-01 DOI:10.1007/s11906-023-01236-6
Sepiso K Masenga, Leta Pilic, Annet Kirabo
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摘要

综述目的:对现有文献进行综述,并提出潜在的机制模型,以帮助我们了解HIV感染/抗逆转录病毒治疗(ART)、盐味敏感性(STS)和血压盐敏感性(SSBP)在高血压发病中的作用。最近的研究发现:上皮钠通道(ENaC)是识别舌头中Na +的主要蛋白/钠通道,在动物和人类中介导对中低盐浓度的偏好。考虑到SSBP患者口服盐的降压反应,不良的STS可能会加重血压。ENaC的特定基因变异与盐味感知和高血压有关。艾滋病毒感染、一些抗逆转录病毒治疗和特定的抗高血压药物与STS降低和对咸味食物的喜爱增加有关。接受抗逆转录病毒治疗的艾滋病毒感染者(PWH)的STS可能会降低,并且患盐敏感性高血压的风险更高。饮食盐介导的炎症是PWH患者STS不良和盐敏感性高血压的驱动因素之一。
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Salt Taste and Salt Sensitive Hypertension in HIV.

Purpose of review: To provide a summary of current literature and propose potential mechanistic models to help us understand the role of HIV infection/antiretroviral therapy (ART), salt taste sensitivity (STS), and salt sensitivity of blood pressure (SSBP) in hypertension development.

Recent findings: The epithelial sodium channel (ENaC) is the main protein/sodium channel for recognizing Na + in the tongue and mediates preference to low-medium salt concentrations in animals and humans. Considering the pressor response to oral salt in individuals with SSBP, poor STS may worsen blood pressure. Specific genetic variants in ENaC are linked to salt taste perception and hypertension. HIV infection, some ART, and specific antihypertensive drugs are associated with reduced STS and an increased liking for salty foods. Persons with HIV (PWH) on ART may have a decreased STS and are at a higher risk of developing salt-sensitive hypertension. Inflammation mediated by dietary salt is one of the drivers of poor STS and salt-sensitive hypertension among PWH.

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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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