新冠肺炎、急性精神疾病和合并症患者炎症标志物和疾病严重程度的比较

IF 2.5 4区 医学 Q2 PSYCHIATRY European Journal of Psychiatry Pub Date : 2023-04-01 DOI:10.1016/j.ejpsy.2022.01.008
Özgecan Tuna , Cagatay Ermis , Asli Enez Darcin , Ekin Dagistan , Serdar Salman
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引用次数: 0

摘要

背景与目的中性粒细胞、淋巴细胞计数、乳酸脱氢酶(LDH)、D-二聚体、纤维蛋白原和合并症与新冠肺炎的病程和预后有关。然而,与新冠肺炎感染重叠的急性严重精神疾病的过程没有得到调查,仍然是一个未经证实的研究领域。这项研究旨在证明炎症标志物和患有这两种疾病的患者的病程。方法纳入38例新冠肺炎合并急性精神病(新冠肺炎+PD)住院患者、31例新冠肺炎住院患者和38例急性精神病住院患者。比较中性粒细胞、淋巴细胞计数、血清铁蛋白、乳酸脱氢酶(LDH)、D-二聚体、纤维蛋白原、全身免疫炎症指数(SII)、中性粒细胞/淋巴细胞比率(NLR)和C反应蛋白(CRP)以评估炎症水平。结果与PD组相比,严重急性呼吸系统综合征冠状病毒2型感染患者的年龄更大。预测新冠肺炎肺炎患者进展风险的CALL(共患病率、年龄、淋巴细胞、乳酸脱氢酶)评分在两个新冠肺炎组中相似。新冠肺炎+PD在研究样本中具有较高的SII。此外,新冠肺炎+PD组的NLR、铁蛋白和CRP水平高于PD组。结论新冠肺炎伴有精神障碍时,预后不会恶化。实验室评估可以指导临床医生区分精神病院内感染严重急性呼吸系统综合征冠状病毒2型的患者。与新冠肺炎组相比,新冠肺炎合并症和精神障碍组的生化评估没有有力地支持更高的炎症水平。
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Comparison of inflammation markers and severity of illness among patients with COVID-19, acute psychiatric disorders and comorbidity

Background and objectives

Neutrophil, lymphocyte counts, lactate dehydrogenase (LDH), D-dimer, fibrinogen, and comorbid illness are associated with the course and prognosis of COVID-19. However, the course of acute severe psychiatric disorders overlapping with COVID-19 infection was not investigated and remained as an unclarified research area. This study aimed to demonstrate inflammatory markers and the course of patients suffering from both conditions.

Methods

Thirty-eight inpatients with COVID-19 and comorbid acute psychiatric disorders (COVID-19+PD), 31 inpatients with COVID-19, and 38 inpatients with an acute psychiatric disorder (PD) were included in the study. Neutrophil, lymphocyte counts, serum ferritin, lactate dehydrogenase (LDH), D-dimer, fibrinogen, Systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), and C-reactive protein (CRP) were compared to evaluate inflammation levels.

Results

Patients with SARS-CoV-2 infection had older age compared to the PD group. CALL (Comorbidity, age, lymphocyte, lactate dehydrogenase) scores which predict the progression risk in patients with COVID-19 pneumonia, of both COVID-19 groups were found similar. The COVID-19+PD had higher SII in the study sample. Additionally, the COVID-19+PD group had higher NLR, ferritin, and CRP levels than those of the PD group.

Conclusions

The prognosis of COVID-19 is not worse when accompanied by a psychiatric disorder. Laboratory assessment can guide clinicians to distinguish those infected with SARS-CoV-2 within psychiatric inpatient units. The biochemical assessment did not robustly support higher inflammatory levels in the comorbid COVID-19 and psychiatric disorder group compared to the COVID-19 group.

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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
40
审稿时长
43 days
期刊介绍: The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
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