接受冠状动脉ct血管造影的高血压患者的主要不良心血管事件与Gensini评分或冠状动脉钙化评分之间的关系

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiology Research Pub Date : 2023-04-01 DOI:10.14740/cr1453

Yuhei Shiga, Kohei Tashiro, Erica Miura, Sara Higashi, Yuto Kawahira, Takashi Kuwano, Makoto Sugihara, Shin-Ichiro Miura

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引用次数: 1

摘要

背景:来自福冈大学冠状动脉计算机断层血管造影(FU-CCTA)登记，我们报告了接受CCTA的高血压患者的主要不良心血管事件(mace)，以及mace与冠状动脉Gensini评分或冠状动脉钙化(CAC)评分之间的关系。方法:在福冈大学医院接受冠心病(CAD)筛查的患者中，纳入318例至少有一种心血管危险因素或疑似冠心病的高血压患者。患者分为两组:恶性肿瘤组和非恶性肿瘤组。冠状动脉粥样硬化的严重程度采用Gensini评分。CCTA时的计算机断层扫描(CT)图像也定义了CAC评分。主要终点是mace(全因死亡、缺血性卒中、急性心肌梗死、冠状动脉血运重建术)。对这些患者进行了长达5年的随访。结果:患者年龄68±10岁，男性占50%。吸烟、血脂异常、糖尿病和慢性肾病的比例分别为39%、70%、26%和37%。mace组男性百分比、吸烟百分比、CAC评分、Gensini评分均显著高于非mace组。另一方面，两组之间在年龄、血脂异常、糖尿病或慢性肾脏疾病方面没有差异。采用logistic回归分析CAC评分或Gensini评分，并将常规危险因素作为自变量，对MACE的存在与否进行多变量分析。Cox回归分析显示CAC评分(P = 0.043)与Gensini评分(P = 0.008)之间存在显著相关。结论:CAC评分和Gensini评分可以预测行CCTA的高血压患者的mace。

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Association Between Major Adverse Cardiovascular Events and the Gensini Score or Coronary Artery Calcification Score in Hypertensive Patients Who Have Undergone Coronary Computed Tomography Angiography.

Background: From the Fukuoka University Coronary Computed Tomography Angiography (FU-CCTA) registry, we present major adverse cardiovascular events (MACEs) in hypertensive patients who have undergone CCTA, and the association between MACEs and the Gensini score of coronary arteries or the coronary artery calcification (CAC) score.

Methods: Of the patients who underwent CCTA for coronary artery disease (CAD) screening at Fukuoka University Hospital, 318 hypertensive patients who had at least one cardiovascular risk factor or suspected CAD were enrolled. The patients were divided into two groups: MACEs and non-MACEs groups. The severity of atherosclerosis of coronary arteries was assessed by the Gensini score. The CAC score was also defined by computed tomography (CT) images at the time of CCTA. A primary endpoint was MACEs (all-cause death, ischemic stroke, acute myocardial infarction, coronary revascularization). The patients were followed for up to 5 years.

Results: The patients were 68 ± 10 years, and 50% were males. The percentages of smoking, dyslipidemia, diabetes, and chronic kidney disease were 39%, 70%, 26% and 37%, respectively. The %males, %smoking, CAC score and Gensini score in the MACEs group were significantly higher than those in the non-MACEs group. On the other hand, the differences in age, dyslipidemia, diabetes, or chronic kidney disease between the groups were not seen. A multivariate analysis was performed regarding the presence or absence of MACE by logistic regression analysis of the CAC score or Gensini score in addition to conventional risk factors as independent variables. A Cox regression analysis revealed significant relationships for both the CAC score (P = 0.043) and the Gensini score (P = 0.008).

Conclusions: The CAC score and the Gensini score could predict MACEs in hypertensive patients who have undergone CCTA.

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

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0.00%

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期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.