铀矿废物暴露的纳瓦霍社区的金属混合物暴露和多重自身抗体筛选

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2023-01-01 DOI:10.1016/j.jtauto.2023.100201
Esther Erdei , Chris Shuey , Curtis Miller , Joseph Hoover , Miranda Cajero , Johnnye Lewis
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引用次数: 0

摘要

dine环境健康网络(DiNEH)项目的1304名纳瓦霍社区成员中有一半以上记录了对铀矿废物和饮用水中金属的环境暴露,这是对纳瓦霍民族接触这些金属和社区健康的首次全面评估。目的利用多重自身抗体阳性作为早期效应生物标志物,评估提供血液和尿液样本的参与者的环境暴露情况。方法采用调查和地理空间定位数据、井水水质和金属生物监测对100个废弃铀废物场地的混合金属废物暴露进行评价。结果:我们观察到,239名参与者中多重自身抗体阳性的患病率是美国人群报告的两倍多(27.2% vs 13.8%),尽管全国患病率是使用不同的测定方法产生的,HEp-2细胞为基础的抗核抗体试验。在DiNEH研究中,居住在铀矿和选矿废料附近以及在饮用水中消耗金属的人群中,发现多重自身抗体筛查阳性的风险增加(OR = 3.07,95%CI 1.15-8.22)。当女性居住在受污染的铀矿和铀矿附近时,这种关联甚至更强。抗u1 - rnp抗体与镍的水消耗有关。结论邻近废物场地和低于现行饮用水标准的水中金属的消耗与免疫耐受的扰动有关。这些发现与先前对当地人群自身免疫的研究一致,并表明多重自身抗体筛查方法有可能作为环境金属暴露的前哨指标。影响声明:这是在暴露的纳瓦霍社区进行的第一次社区参与的环境健康研究,该研究应用临床多重测试来评估与废弃的、未修复的铀矿开采和磨矿废物场有关的环境金属的风险。常规临床自身免疫指标可作为环境金属暴露的早期效应生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Metal mixture exposures and multiplexed autoantibody screening in Navajo communities exposed to uranium mine wastes

Background

Environmental exposures to metals in uranium mining wastes and drinking water were documented in more than half of the 1304 Navajo community members of the Diné Network for Environmental Health (DiNEH) Project, the first comprehensive assessment of exposures to these metals and community health on the Navajo Nation.

Objective

Evaluate environmental exposures among participants who provided blood and urine samples using multiplexed autoantibody positivity as an early effect biomarker.

Methods

Survey and geospatial location data, well water quality, and metals biomonitoring were used to assess exposures to mixed-metal wastes from 100 abandoned uranium waste sites.

Results

We observed that the prevalence of multiplexed autoantibody positivity in 239 participants was more than double that reported for the U.S. population (27.2% v. 13.8%) even though the national prevalence was generated using a different assay, the HEp-2 cell-based antinuclear antibody test. Increased risk of multiplexed autoantibody screening positivity (OR = 3.07,95%CI 1.15–8.22) was found among DiNEH study people who lived close to uranium mine and milling wastes and consumed metals in drinking water. Associations for females were even stronger when they lived closed to contaminated uranium mining and milling sites. Anti-U1-RNP antibodies were associated with water consumption of nickel.

Conclusion

Proximity to waste sites and consumption of metals in water even below current drinking water standards were associated with perturbations of immune tolerance. These findings are consistent with previous studies of autoimmunity in the local population and demonstrate that multiplexed autoantibody screening method has a potential as sentinel indicator of exposures to environmental metals.

Impact statement

This is the first, community-engaged environmental health study in exposed Navajo communities that applied clinical multiplexed testing in risk assessment of environmental metals associated with abandoned, unremediated uranium mining and milling waste sites. Routine clinical autoimmunity measures could be used as early effect biomarkers of environmental metal exposures.

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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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