苯二甲酸:有哪些潜在用途?

IF 1.7 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS European Heart Journal Supplements Pub Date : 2023-05-01 DOI:10.1093/eurheartjsupp/suad012
Ilaria Jacomelli, Luca Monzo, Germana Panattoni, Chiara Lanzillo, Marco Rebecchi, Leonardo Calò
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引用次数: 0

摘要

尽管使用他汀类药物、依折麦布和蛋白转化酶枯草菌素/ 9型酮素,仍有降低LDL-c的需要。患有动脉粥样硬化性心血管疾病和/或家族性高胆固醇血症的患者在最大耐受剂量下使用他汀类药物治疗,同时使用或不使用进一步的降脂药物,但通常,我们无法达到目标,因此,在不同的患者群体中,苯戊二酸治疗导致低密度脂蛋白胆固醇显著降低,具有良好的安全性。
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Bempedoic acid: what prospective uses?

There is still the need to lower LDL-c, although the use of statins, ezetimibe and proprotein convertase subtilisin/kexin type 9. Patients with atherosclerotic cardiovascular disease and/or familial hypercholesterolaemia are treated with statins at maximum tolerated dose, with or without further lipid-lowering drugs, but very often, we can't reach the goal, so bempedoic acid treatment lead to a significant reduction in low-density lipoprotein cholesterol, in different groups of patients, with a favourable safety profile.

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来源期刊
European Heart Journal Supplements
European Heart Journal Supplements 医学-心血管系统
CiteScore
3.00
自引率
0.00%
发文量
575
审稿时长
12 months
期刊介绍: The European Heart Journal Supplements (EHJs) is a long standing member of the ESC Journal Family that serves as a publication medium for supplemental issues of the flagship European Heart Journal. Traditionally EHJs published a broad range of articles from symposia to special issues on specific topics of interest. The Editor-in-Chief, Professor Roberto Ferrari, together with his team of eminent Associate Editors: Professor Francisco Fernández-Avilés, Professors Jeroen Bax, Michael Böhm, Frank Ruschitzka, and Thomas Lüscher from the European Heart Journal, has implemented a change of focus for the journal. This entirely refreshed version of the European Heart Journal Supplements now bears the subtitle the Heart of the Matter to give recognition to the focus the journal now has. The EHJs – the Heart of the Matter intends to offer a dedicated, scientific space for the ESC, Institutions, National and Affiliate Societies, Associations, Working Groups and Councils to disseminate their important successes globally.
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