激活NKG2C受体:功能特征及当前临床应用策略

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2023-03-10 DOI:10.1007/s00005-023-00674-z
Jagoda Siemaszko, Aleksandra Marzec-Przyszlak, Katarzyna Bogunia-Kubik
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引用次数: 0

摘要

随着NK细胞成为免疫治疗中一种新的、有效的现成药物,人们对NK细胞及其对肿瘤、感染或转化细胞的细胞毒性活性的兴趣不断增加。它们的作用通过广泛的激活和抑制受体来平衡,识别它们在靶细胞上的互补配体。研究最多的受体之一是活化CD94/NKG2C分子,它是c型凝集素样家族的成员。本文旨在总结NKG2C受体临床相关性的最新研究成果,并探讨其对当前和潜在治疗策略的贡献。概述了CD94/NKG2C的功能特征和分子特征,及其与HLA-E分子和呈递抗原的相互作用,指出了该受体在免疫监视中,特别是在人巨细胞病毒感染中的关键作用。此外,作者试图阐明受体与其配体的独特相互作用,该配体与另一个具有相反性质的受体(CD94/NKG2A)共享。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells. One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies. It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this receptor in immunosurveillance, especially in the human cytomegalovirus infection. Additionally, the authors attempt to shed some light on receptor’s unique interaction with its ligand which is shared with another receptor (CD94/NKG2A) with rather opposite properties.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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