虚拟记忆 T 细胞在疾病中的作用

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2023-02-20 eCollection Date: 2023-02-01 DOI:10.4110/in.2023.23.e11
Joon Seok, Sung-Dong Cho, Seong Jun Seo, Su-Hyung Park
{"title":"虚拟记忆 T 细胞在疾病中的作用","authors":"Joon Seok, Sung-Dong Cho, Seong Jun Seo, Su-Hyung Park","doi":"10.4110/in.2023.23.e11","DOIUrl":null,"url":null,"abstract":"<p><p>Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a \"memory-like\" T-cell population, termed virtual memory T (T<sub>VM</sub>) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, T<sub>VM</sub> cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of T<sub>VM</sub> cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.</p>","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/cb/in-23-e11.PMC9995991.pdf","citationCount":"0","resultStr":"{\"title\":\"Roles of Virtual Memory T Cells in Diseases.\",\"authors\":\"Joon Seok, Sung-Dong Cho, Seong Jun Seo, Su-Hyung Park\",\"doi\":\"10.4110/in.2023.23.e11\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a \\\"memory-like\\\" T-cell population, termed virtual memory T (T<sub>VM</sub>) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, T<sub>VM</sub> cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of T<sub>VM</sub> cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.</p>\",\"PeriodicalId\":13307,\"journal\":{\"name\":\"Immune Network\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2023-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/cb/in-23-e11.PMC9995991.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immune Network\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4110/in.2023.23.e11\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/2/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immune Network","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4110/in.2023.23.e11","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

记忆 T 细胞通常是在识别外来抗原后产生的,它能快速有效地抵御再感染。不过,也有报道称,有一种 "类似记忆 "的 T 细胞群,即虚拟记忆 T 细胞(TVM),可在没有外来抗原的情况下获得记忆表型。据报道,TVM 细胞与先天性细胞一样,在细菌或病毒感染的第一线防御中发挥作用,但它们在免疫相关疾病中的保护或病理作用在很大程度上还不为人所知。在这篇综述中,我们将讨论目前对 TVM 细胞的认识,重点是它们的独特特征、免疫学特性以及在各种免疫相关疾病(如感染和癌症)中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Roles of Virtual Memory T Cells in Diseases.

Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a "memory-like" T-cell population, termed virtual memory T (TVM) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, TVM cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of TVM cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
期刊最新文献
Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes. A Dynamic Interplay of Innate Immune Responses During Urinary Tract Infection. Multi-Layered Mechanisms of Immunological Tolerance at the Maternal-Fetal Interface. The Multifaceted Roles of NK Cells in the Context of Murine Cytomegalovirus and Lymphocytic Choriomeningitis Virus Infections. Germinal Center Response to mRNA Vaccination and Impact of Immunological Imprinting on Subsequent Vaccination.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1