一种伤口友好的抗菌透明质酸敷料,可按需去除,用于感染伤口愈合。

IF 11.3 1区 医学 Q1 Medicine Biomaterials Research Pub Date : 2023-05-01 DOI:10.1186/s40824-023-00340-7
Datao Hu, Jinpeng Wen, Xinxin Zhao, Kailai Liu, Yuchen Zhang, Yizhuo Bu, Ke Wang
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引用次数: 1

摘要

背景:抗菌活性和按需去除性是控制临床伤口敷料有效性的关键特征。然而,新敷料良好的组织粘附性往往被过分强调,而没有详细讨论敷料更换。此外,敷料固有的抗菌能力有利于促进感染伤口的愈合。因此,我们合理设计了一种可按需去除的可注射抗菌创面敷料,以加速感染创面的愈合。方法:利用透明质酸和ε-聚赖氨酸的静电自组装,设计一种简单可行的创面敷料。我们通过各种试验,从微形貌、流变学、自愈性能、粘附能力、抗菌、止血、按需去除性能和促进伤口愈合等方面考察了这种敷料的功效。结果:制备的敷料具有可注射性、自愈性和抗菌活性,由于静电相互作用的破坏,表现出nacl触发的按需溶解。作为全层创面的敷料,其优异的粘附能力、良好的止血性能和较强的抗菌性能,能有效地促进创面愈合,杀灭细菌、下调炎症、促进胶原沉积、促进角质细胞迁移和血管生成。结论:本发明是一种简便实用的临床敷料。该策略为开发具有抗菌和注射性能的按需去除敷料提供了新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A wound-friendly antibacterial hyaluronic acid dressing with on-demand removability for infected wound healing.

Background: Antibacterial activity and on-demand removability are key characteristics governing the effectiveness of clinic wound dressing. However, the excellent tissue adhesion of new dressings is often overemphasized without a detailed discussion of dressing replacement. Besides, the inherent antibacterial ability of dressings is beneficial for promoting the healing of infected wound. Therefore, we rationally design an injectable antibacterial wound dressing with on-demand removability to accelerate infected wound healing.

Method: We design this wound dressing with a simple and feasible method based on the electrostatic self-assembly of hyaluronic acid and ε-polylysine. We investigated the efficacy of this dressing in terms of its microtopography, rheology, self-healing performance, adhesive ability, antimicrobial, hemostatic, on-demand removal properties, and wound healing promotion through various tests.

Results: The prepared dressing possesses injectability, self-healing ability and antibacterial activity, showing NaCl-triggered on-demand dissolution due to the disruption of electrostatic interactions. When used as dressings for healing full-thickness wounds, it could effectively accelerate wound healing by killing bacteria, downregulating inflammation, promoting collagen deposition, enhancing keratinocyte migration and angiogenesis due to its excellent adhesion ability, favorable hemostatic property, and potent antibacterial performance.

Conclusion: All results indicate that this is a simple and practical dressing for clinical application. This strategy provides a novel idea for developing on-demand removal dressings with antibacterial and injectable properties.

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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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