杀伤细胞免疫球蛋白样受体三域长胞浆尾1基因*007可能调节日本人群人类免疫缺陷病毒-1感染的疾病进展

IF 2.3 4区 医学 Q3 GENETICS & HEREDITY International Journal of Immunogenetics Pub Date : 2023-02-17 DOI:10.1111/iji.12617
Taeko K. Naruse, Makiko Konishi-Takemura, Risa Yanagida, Gaurav Sharma, Madhu Vajpayee, Hiroshi Terunuma, Narinder K. Mehra, Gurvinder Kaur, Akinori Kimura
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引用次数: 0

摘要

在日本和印度人群中,其中一个KIR等位基因KIR3DL1*007与获得性免疫缺陷综合征的进展有关,而与HIV-1感染的易感性无关,这意味着KIR3DL1*007阳性NK细胞可能比携带其他KIR3DL1等位基因或KIR3DS1等位基因的NK细胞消除hiv感染细胞的效率要低。
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Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 1 gene *007 may modulate disease progression of human immunodeficiency virus-1 infection in the Japanese population

One of the KIR allele, KIR3DL1*007, was associated with the progression to acquired immunodeficiency syndrome and not with the susceptibility to HIV-1 infection in the Japanese and Indian populations, implying that KIR3DL1*007-positive NK cells might eliminate HIV-infected cells less effectively than NK cells bearing the other KIR3DL1 alleles or KIR3DS1 alleles.

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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
48
审稿时长
6-12 weeks
期刊介绍: The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.
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