慢性肾脏疾病日益增长的挑战:当前知识综述。

IF 1.7 Q3 UROLOGY & NEPHROLOGY International Journal of Nephrology Pub Date : 2023-01-01 DOI:10.1155/2023/9609266
Rikke Borg, Nicholas Carlson, Jens Søndergaard, Frederik Persson
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引用次数: 0

摘要

慢性肾脏疾病(CKD)正在成为世界上最普遍的非传染性慢性疾病之一。世界卫生组织预计,到2040年,慢性肾脏病将成为第五大最常见的慢性病。CKD的病因是多因素和多样的,但早期症状往往很少和沉默。进展率变化很大,但患者患终末期肾病(ESKD)的风险增加,心血管风险也增加。终末期肾病的发病率一般较低,但每一个病例都有重大的疾病负担和医疗费用,因此通过早期干预进行预防是可取的和值得的。本文综述了慢性肾病的患病率、诊断和病因。此外,我们讨论CKD的一般治疗的发展,特别关注在一般实践中可以启动的。随着最近具有里程碑意义的发现和使用钠-葡萄糖共转运蛋白2抑制剂适应症的扩大,现在有新的有效治疗方法可以添加到标准治疗中。这也与初级保健医生有关,因为许多CKD患者的家庭医生是他们处理肾功能保护的初级保健专业人员。在未来,更精确和更少侵入性的诊断方法不仅可以提高对CKD潜在原因的确定,还可以提供有关使用哪种治疗方法的信息(即个性化医疗)。这可能导致每个人预防性治疗的数量减少,同时改善预后。本综述总结了这一领域正在进行的努力。
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The Growing Challenge of Chronic Kidney Disease: An Overview of Current Knowledge.

Chronic kidney disease (CKD) is becoming one of the world's most prevalent noncommunicable chronic diseases. The World Health Organization projects CKD to become the 5th most common chronic disease in 2040. Causes of CKD are multifactorial and diverse, but early-stage symptoms are often few and silent. Progression rates are highly variable, but patients encounter both an increased risk for end-stage kidney disease (ESKD) as well as increased cardiovascular risk. End-stage kidney disease incidence is generally low, but every single case carries a significant burden of illness and healthcare costs, making prevention by early intervention both desirable and worthwhile. This review focuses on the prevalence, diagnosis, and causes of CKD. In addition, we discuss the developments in the general treatment of CKD, with particular attention to what can be initiated in general practice. With the addition of recent landmark findings and the expansion of the indication for using sodium-glucose cotransporter 2 inhibitors, there are now new effective treatments to add to standard therapy. This will also be relevant for primary care physicians as many patients with CKD have their family physician as their primary health care professional handling kidney function preservation. In the future, more precise and less invasive diagnostic methods may not only improve the determination of the underlying cause of CKD but may also carry information regarding which treatment to use (i.e. personalized medicine). This could lead to a reduced number of preventive treatments per individual, while at the same time improving the prognosis. This review summarizes ongoing efforts in this area.

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来源期刊
International Journal of Nephrology
International Journal of Nephrology UROLOGY & NEPHROLOGY-
CiteScore
3.40
自引率
4.80%
发文量
44
审稿时长
17 weeks
期刊介绍: International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.
期刊最新文献
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