生理性别影响符号追踪和焦虑样行为对瑞芬太尼自我给药的贡献。

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2023-06-01 DOI:10.1037/bne0000551
Alicia Zumbusch, Anna Samson, Chloe Chernoff, Brandi Coslovich, Tristan Hynes
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引用次数: 0

摘要

大多数人吸食成瘾药物,但只有一小部分人使用成瘾。影响成瘾易感性的两个重要因素是人格特征的个体差异和生理性别。特征对成瘾样行为的影响在可卡因自我给药的临床前模型中得到了很好的表征,但在阿片类药物方面却知之甚少。与精神兴奋剂相比,生理性别如何影响阿片类药物自我给药的特质易感性同样较少研究。因此,我们试图阐明生理性别和一些与成瘾相关的特征如何与自我使用阿片类药物瑞芬太尼的倾向相互作用。我们首先筛选了雌性(n = 19)和雄性(n = 19)大鼠的四种与成瘾相关的特征:冲动、新奇的地方偏好、焦虑样行为和奖励线索的激励价值归因。然后在药物自我给药的“冲突模型”中训练大鼠自我给药瑞芬太尼。老鼠必须忍受电击才能进入触发静脉注射瑞芬太尼的反应操纵机制。在雄性大鼠中,如果休克水平较低或完全不存在,高度焦虑样行为与药物输注次数呈正相关。在女性中,符号追踪预示着她们在寻求毒品时对惩罚的抵抗力更强;这种效应是由类似焦虑的行为介导的。在所有条件下,女性消耗更多的瑞芬太尼,并且她们的药物寻求在面对明显大于男性的电流时持续存在。这些发现表明,行为特征对自我使用阿片类药物倾向的影响取决于生理性别。(PsycInfo数据库记录(c) 2023 APA,版权所有)。
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Biological sex influences the contribution of sign-tracking and anxiety-like behavior toward remifentanil self-administration.

Most people sample addictive drugs, but use becomes disordered in only a small minority. Two important factors that influence susceptibility to addiction are individual differences in personality traits and biological sex. The influence of traits on addiction-like behavior is well-characterized in preclinical models of cocaine self-administration, but less is understood in regards to opioids. How biological sex influences trait susceptibility to opioid self-administration is likewise less studied than psychostimulants. Thus, we sought to elucidate how biological sex and several addiction-relevant traits interact with the propensity to self-administer the opioid remifentanil. We first screened female (n = 19) and male (n = 19) rats for four addiction-relevant traits: impulsivity, novelty place-preference, anxiety-like behavior, and attribution of incentive value to reward cues. Rats were then trained to self-administer remifentanil in a "conflict model" of drug self-administration. Rats had to endure an electric shock to access the response manipulandum that triggered an intravenous infusion of remifentanil. In male rats, high anxiety-like behavior was positively correlated with the number of drug infusions if the shock level was low or completely absent. In females, sign-tracking was predictive of greater resistance to punishment during drug seeking; an effect that was mediated by anxiety-like behavior. Females consumed more remifentanil under all conditions, and their drug seeking persisted in the face of significantly greater current than males. These findings demonstrate that the influence of behavioral traits over the propensity to self-administer opioids is dependent upon biological sex. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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