细胞外小泡是慢性阻塞性肺疾病病理生理学的核心介质。

IF 15.7 1区 医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-11-01 DOI:10.1146/annurev-physiol-061121-035838
Derek W Russell, Kristopher R Genschmer, J Edwin Blalock
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引用次数: 0

摘要

慢性阻塞性肺疾病(COPD)是一种复杂的、异质性的、与吸烟有关的疾病,对全球具有重大影响。慢性阻塞性肺病复杂的生物学过程最终是由几个相互关联的过程驱动的,包括蛋白水解组织重塑、先天性免疫炎症、宿主-病原体反应失常、细胞表型异常转换和细胞衰老等。这些过程中的每一个过程都是通过细胞调节其环境或细胞间的相互作用而产生和延续的。细胞外囊泡(EVs)是一种强大的效应器,能让细胞对邻近和远处的组织发挥各种功能,而人们对它们的多效应性质的认识才刚刚开始。因此,EVs 有可能在慢性阻塞性肺病背后的这些基本疾病机制中发挥重要作用。此外,EVs 的某些作用已经确立,EVs 与慢性阻塞性肺病发病机制的重要方面有牵连。在此,我们将讨论 EVs 调节其起源细胞环境以促进慢性阻塞性肺病发病过程的已知和潜在方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Extracellular Vesicles as Central Mediators of COPD Pathophysiology.

Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, smoking-related disease of significant global impact. The complex biology of COPD is ultimately driven by a few interrelated processes, including proteolytic tissue remodeling, innate immune inflammation, derangements of the host-pathogen response, aberrant cellular phenotype switching, and cellular senescence, among others. Each of these processes are engendered and perpetuated by cells modulating their environment or each other. Extracellular vesicles (EVs) are powerful effectors that allow cells to perform a diverse array of functions on both adjacent and distant tissues, and their pleiotropic nature is only beginning to be appreciated. As such, EVs are candidates to play major roles in these fundamental mechanisms of disease behind COPD. Furthermore, some such roles for EVs are already established, and EVs are implicated in significant aspects of COPD pathogenesis. Here, we discuss known and potential ways that EVs modulate the environment of their originating cells to contribute to the processes that underlie COPD.

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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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