照顾慢性病儿童对HPA轴的影响:一项范围审查

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Frontiers in Neuroendocrinology Pub Date : 2023-04-01 DOI:10.1016/j.yfrne.2023.101062

Lindsey Mountcastle , Melissa Zajdel , Taylor Robinson , Krystyna R. Keller , Shani Gelles , Alicia A. Livinski , Bijal Kikani , Dawn E. Lea , Laura M. Koehly

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引用次数: 0

摘要

在照顾患有慢性病的成年人的过程中，通过下丘脑-垂体-肾上腺（HPA）轴的失调，照顾与照顾者的健康密切相关。然而，很少有研究考察照顾患有慢性病的儿童的生理影响，尽管负担很重，压力很大。在这篇综述中，我们探讨了照顾患有先天性、染色体或遗传性疾病的儿童与HPA轴的调节或失调之间的联系。在PubMed、Embase和Web of Science上进行了搜索，有15项研究符合入选标准。总体而言，照顾与HPA轴功能之间存在不一致的联系，这可能是由于疾病背景、研究设计和生物标志物测量的异质性。未来的研究应该使测量和研究设计标准化，增加参与者的多样性，并检查照顾与HPA轴之间联系的调节因素。

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The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review

Caregiving has been robustly linked to caregiver health through the dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis in the context of caregiving for an adult with a chronic illness. However, little research examines the physiological impact of caregiving for a child with a chronic illness despite high burden and unique stressors. In this review, we explore the links of caregiving for a child with a congenital, chromosomal, or genetic disorder to the regulation or dysregulation of the HPA axis. A search was conducted in PubMed, Embase, and the Web of Science and 15 studies met inclusion criteria. Overall, there were inconsistent links of caregiving to HPA axis functioning, perhaps due to the heterogeneity across disease contexts, study designs, and biomarker measurement. Future research should standardize measurement and study designs, increase participant diversity, and examine moderators of the links of caregiving to the HPA axis.

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.