无淀粉样变性的获得性因子X缺乏伴大量血尿1例报告及文献复习。

IF 1.1 Q4 HEMATOLOGY Hematology Reports Pub Date : 2023-05-15 DOI:10.3390/hematolrep15020032
Sasmith R Menakuru, Vijaypal S Dhillon, Ahmed Salih, Amir F Beirat
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引用次数: 0

摘要

获得性因子X缺乏是一种罕见的诊断,特别是没有其他共存的条件,如淀粉样变性的关联。作者报告的情况下,34岁男性严重坦白血尿发现有明显延长凝血酶原时间和活化部分凝血活素时间。一项混合研究显示,校正使用正常血浆和凝血板测试显示降低因子X活性。患者接受多次输血、新鲜冷冻血浆、大剂量脉冲类固醇和利妥昔单抗治疗。患者住院21天病情好转,每2周随访一次,随访3个月。出院两周后患者因子X水平恢复,无其他出血事件。
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Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature.

Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. The authors report the case of a 34-year-old male with severe frank hematuria found to have markedly prolonged prothrombin time and activated partial thromboplastin time. A mixing study showed correction utilizing normal plasma and a coagulation panel testing revealed decreased factor X activity. The patient was treated with multiple blood transfusions, fresh frozen plasma, high-dose pulse steroids, and rituximab. The patient's condition improved during his 21-day hospital stay and was followed up every 2 weeks for 3 months. The patient's factor X level recovered after two weeks of discharge with no other hemorrhagic episodes.

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来源期刊
Hematology Reports
Hematology Reports HEMATOLOGY-
CiteScore
0.90
自引率
0.00%
发文量
47
审稿时长
10 weeks
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