室管膜瘤的最新进展:挑战和治疗机会。

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY Pediatric Neurosurgery Pub Date : 2023-01-01 Epub Date: 2023-05-02 DOI:10.1159/000530868

Kelsey C Bertrand, Paul Klimo

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引用次数: 1

摘要

背景:室管膜瘤是儿童最常见的恶性脑肿瘤之一，并且很难治疗。在过去的十年中，在了解这组肿瘤的潜在分子驱动因素方面取得了很大进展，但临床结果仍未改变。摘要:在这里，我们回顾了儿童室管膜瘤的最新分子进展，评估了最近的临床试验结果，并讨论了该领域正在面临的挑战和仍然存在的问题。在过去的几十年里，室管膜瘤的领域发生了巨大的变化，现在描述了十个不同的分子亚群，但在开发新的治疗策略和靶点方面需要取得很大的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Advancements in Ependymoma: Challenges and Therapeutic Opportunities.

Background: Ependymoma is one of the most common malignant pediatric brain tumors and can be difficult to treat. Over the last decade, much progress has been made in the understanding of the underlying molecular drivers within this group of tumors, but clinical outcomes remain unchanged.

Summary: Here, we review the most recent molecular advances in pediatric ependymoma, evaluate results of recent clinical trials and discuss the ongoing challenges in the field and questions that remain.

Key messages: The field of ependymoma has vastly changed over the last several decades with ten distinct molecular subgroups now described, but much progress needs to be made in developing new therapeutic strategies and targets.

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来源期刊

Pediatric Neurosurgery 医学-临床神经学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Articles in ''Pediatric Neurosurgery'' strives to publish new information and observations in pediatric neurosurgery and the allied fields of neurology, neuroradiology and neuropathology as they relate to the etiology of neurologic diseases and the operative care of affected patients. In addition to experimental and clinical studies, the journal presents critical reviews which provide the reader with an update on selected topics as well as case histories and reports on advances in methodology and technique. This thought-provoking focus encourages dissemination of information from neurosurgeons and neuroscientists around the world that will be of interest to clinicians and researchers concerned with pediatric, congenital, and developmental diseases of the nervous system.