系统性硬化症的手脚影像学表现。

IF 2.1 Q3 RHEUMATOLOGY BMC Rheumatology Pub Date : 2023-05-20 DOI:10.1186/s41927-023-00336-9
Fatemeh Badiee, Alireza Fatemi, Reza Zahedpasha, Mohammad Hadi Gharib, Mohammadhassan Jokar, Somayeh Livani, Mehrdad Aghaie, Nafiseh Abdolahi
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引用次数: 0

摘要

目的:系统性硬化症(SSc)是一种罕见的自身免疫性疾病,其特征是血管和纤维化累及皮肤和内脏器官。在这项研究中,我们确定了伊朗SSc患者放射学上手脚受累的患病率和特征,以确定临床特征与放射学表现之间的关系。方法:43例SSc患者(女41例,男2例),中位年龄44.8岁(26 ~ 70岁),平均病程11.8年(2 ~ 28年)。结果:42例患者手脚均有影像学改变。只有一个病人做了修改。我们发现手部最常见的变化是关节旁骨质疏松症(93%)、肢端骨溶解(58.2%)和关节间隙狭窄(55.8%)。活动性皮肤受累患者关节间隙狭窄或肢端骨溶解的发生率更高[改良罗德曼皮肤评分(mRSS) > 14][16/21对4/16]非活动性皮肤受累患者(mRSS)。结论:本研究证实SSc患者普遍存在关节病变。引入SSc的具体放射学影响需要进一步的研究来证实,以便确定患者的适当预后和治疗。
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Hands and feet radiologic involvements in systemic sclerosis.

Aim: Systemic sclerosis (SSc) is a rare autoimmune disorder characterized by vascular and fibrosing involvement of the skin and internal organs. In this study, we determined the prevalence and characteristics of radiological hands and feet involvements in Iranian SSc patients to identify the associations between clinical features and radiologic findings.

Methods: 43 SSc patients (41 women and 2 men), with a median age of 44.8 years (ranges 26-70 years) and a mean disease duration of 11.8 years (ranges 2-28 years) were studied in this cross-sectional study.

Results: 42 patients had radiological changes both in their hands and feet. Only one patient had alteration just in hand. The most frequent changes that we found in hand were Juxta-articular Osteoporosis (93%), Acro-osteolysis (58.2%), and Joint Space Narrowing (55.8%). The prevalence of joint space narrowing or acro-osteolysis was higher in subjects with active skin involvement [modified Rodnan skin score (mRSS) > 14] [16/21 vs. 4/16 for patients with inactive skin involvement (mRSS < 14); p = 0.002]. The most frequent changes that we found in the foot were Juxta-articular Osteoporosis (93%), Acro-osteolysis (46.5%), Joint Space Narrowing (58.1%), and subluxation (44.2%). The presence of anti-ccp antibody was detected in 4 (9.3%), while positive rheumatoid factor was found in 13 (30.2%) of SSc patients.

Conclusion: This study corroborates that arthropathy is common in SSc patients. The introduction of the specific radiological involvements of SSc needs to be confirmed by further studies, in order to define the appropriate prognosis and treatment of patients.

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来源期刊
BMC Rheumatology
BMC Rheumatology Medicine-Rheumatology
CiteScore
3.80
自引率
0.00%
发文量
73
审稿时长
15 weeks
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