IL-12A基因中的rs568408变异与伊拉克患者患COVID-19的风险有关。

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Tzu Chi Medical Journal Pub Date : 2023-04-01 DOI:10.4103/tcmj.tcmj_223_22
Falah Hasan Obayes Al-Khikani, Zaytoon Abdulridha Alkhafaji
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引用次数: 1

摘要

目的:本研究的目的是检查伊拉克人群中IL12A rs568408的潜在多态性与COVID-19可能风险之间的联系。材料与方法:采用等位基因特异性聚合酶链反应(PCR)技术对125例COVID-19重症病例和60例对照患者进行基因分型和IL12A rs568408基因多态性检测。2022年1月至6月期间,伊拉克的马尔詹医疗城或Al-Sadeq医院的COVID-19病房收治了患者。所有患者均经严重急性呼吸道冠状病毒2型阳性逆转录pcr检测确诊为COVID-19。结果:IL-12A rs568408基因分型分布及等位基因频率在患者与对照组间差异均有统计学意义(P = 0.006, P = 0.001)。IL12A rs568408 AA和AG变异基因型与COVID-19风险显著增加相关(优势比[OR] = 5.19, 95%可信区间[CI]: 1.13-23.82;P = 0.034)和(OR = 2.39, 95% CI = 1.16-4.94, P = 0.018)。结论:IL12A rs568408 GA/AA变异可能与COVID-19的风险有关。本研究首次报道了IL12A rs568408与COVID-19的关联。
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The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients.

Objectives: The objective of the current study was to check the link between potential polymorphism in IL12A rs568408 and the possible risk of COVID-19 in the Iraqi population.

Materials and methods: Allele specific-polymerase chain reaction (PCR) technique was carried out for genotyping and detection of IL12A rs568408 gene polymorphism in a case-control study of 125 severe COVID-19 cases and 60 controls. Patients were admitted to either Marjan medical city or Al-Sadeq hospital's COVID-19 wards between January and June 2022 in Iraq. The diagnosis of COVID-19 in each patient was confirmed by severe acute respiratory coronavirus 2-positive reverse transcription-PCR.

Results: The distribution of both genotyping and allele frequencies of IL-12A rs568408 revealed significant differences between patients and control groups (P = 0.006 and P = 0.001, respectively). The IL12A rs568408 AA and AG variant genotypes were associated with a significantly increased risk of COVID-19 (odds ratio [OR] = 5.19, 95% confidence interval [CI]: 1.13-23.82; P = 0.034) and (OR = 2.39, 95% CI = 1.16-4.94, P = 0.018), respectively, compared with the wild-type GG homozygote.

Conclusion: These findings indicate that IL12A rs568408 GA/AA variant may contribute to the risk of COVID-19. This study is the first report about the association of IL12A rs568408 with COVID-19.

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来源期刊
Tzu Chi Medical Journal
Tzu Chi Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.40
自引率
0.00%
发文量
44
审稿时长
13 weeks
期刊介绍: The Tzu Chi Medical Journal is the peer-reviewed publication of the Buddhist Compassion Relief Tzu Chi Foundation, and includes original research papers on clinical medicine and basic science, case reports, clinical pathological pages, and review articles.
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