传染病的类器官模型。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Annual review of medicine Pub Date : 2022-01-27 DOI:10.1146/annurev-med-042320-023055
Sarah E Blutt, Mary K Estes
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引用次数: 15

摘要

传染病影响个人健康,并具有广泛的社会影响。新的离体模型对于了解发病机制、宿主反应以及开发预防和治疗方法所必需的特征至关重要。多能干细胞和组织干细胞衍生的类器官为人类感染的研究提供了新的工具。类器官模型概括了体内疾病的许多特征,并为人类呼吸,胃肠道和神经宿主-微生物相互作用提供了新的见解。通过增加基质、器官间交流和微生物组来增加培养的复杂性,将改善类器官作为感染模型的使用。类器官培养提供了一个平台,有能力改善与传染病有关的人类健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Organoid Models for Infectious Disease.

Infectious diseases affect individual health and have widespread societal impacts. New ex vivo models are critical to understand pathogenesis, host response, and features necessary to develop preventive and therapeutic treatments. Pluripotent and tissue stem cell-derived organoids provide new tools for the study of human infections. Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions. Increasing culture complexity by adding the stroma, interorgan communication, and the microbiome will improve the use of organoids as models for infection. Organoid cultures provide a platform with the capability to improve human health related to infectious diseases.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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