针灸通过恢复额前皮质神经可塑性来缓解CUMS诱导的抑郁样行为。

IF 3 4区 医学 Q2 NEUROSCIENCES Neural Plasticity Pub Date : 2023-05-02 eCollection Date: 2023-01-01 DOI:10.1155/2023/1474841
Peng Li, Wenya Huang, Yiping Chen, Muhammad Shahzad Aslam, Wenjing Cheng, Yang Huang, Wenjie Chen, Yanxun Huang, Xinnan Wu, Yining Yan, Junliang Shen, Tao Tong, Shuqiong Huang, Xianjun Meng
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引用次数: 1

摘要

目的:探讨针灸治疗抑郁症的疗效及神经可塑性的相关分子机制。方法:建立慢性不可预测轻度应激(CUMS)诱导的大鼠抑郁症动物模型。共有四个大鼠组,包括对照组、CUMS组、CUMS+针刺组和CUMS+氟西汀组。针刺组和氟西汀组在模型干预后给予3周的治疗。研究人员进行了开阔场地、高架加迷宫和蔗糖偏好测试来评估抑郁行为。用高尔基染色法检测神经细胞的数量、树突的长度和前额叶皮层的脊椎密度。结果:针刺可减轻抑郁样行为,促进前额叶皮层神经可塑性功能的恢复,表现为细胞数量增加,树突长度延长,脊柱密度增加。前额叶皮层的神经可塑性相关蛋白,包括BDNF、PSD95、SYN和PKMZ,在CUMS诱导组中均下调;结论:针刺可通过促进CUMS诱导的抑郁大鼠前额叶皮层神经可塑性功能的恢复和神经可塑性相关蛋白的上调来改善抑郁样行为。我们的研究为抗抑郁方法提供了新的见解,需要进一步的研究来阐明针灸在抑郁症治疗中的作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity.

Purpose: To explore the therapeutic efficiency of acupuncture and the related molecular mechanism of neural plasticity in depression.

Methods: Chronic unpredictable mild stress- (CUMS-) induced rats were established for the depression animal model. There were a total of four rat groups, including the control group, the CUMS group, the CUMS+acupuncture group, and the CUMS+fluoxetine group. The acupuncture group and the fluoxetine group were given a 3-week treatment after the modeling intervention. The researcher performed the open-field, elevated plus maze, and sucrose preference tests to evaluate depressive behaviors. The number of nerve cells, dendrites' length, and the prefrontal cortex's spine density were detected using Golgi staining. The prefrontal cortex expression, such as BDNF, PSD95, SYN, and PKMZ protein, was detected using the western blot and RT-PCR.

Results: Acupuncture could alleviate depressive-like behaviors and promote the recovery of the neural plasticity functions in the prefrontal cortex, showing the increasing cell numbers, prolonging the length of the dendrites, and enhancing the spine density. The neural plasticity-related proteins in the prefrontal cortex, including BDNF, PSD95, SYN, and PKMZ, were all downregulated in the CUMS-induced group; however, these effects could be partly reversed after being treated by acupuncture and fluoxetine (P < 0.05).

Conclusion: Acupuncture can ameliorate depressive-like behaviors by promoting the recovery of neural plasticity functions and neural plasticity-related protein upregulation in the prefrontal cortex of CUMS-induced depressed rats. Our study provides new insights into the antidepressant approach, and further studies are warranted to elucidate the mechanisms of acupuncture involved in depression treatment.

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来源期刊
Neural Plasticity
Neural Plasticity NEUROSCIENCES-
CiteScore
6.80
自引率
0.00%
发文量
77
审稿时长
16 weeks
期刊介绍: Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.
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