糖尿病对潜伏结核感染免疫的影响。

Nathella Pavan Kumar, Subash Babu
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引用次数: 1

摘要

结核病是一种传染性疾病,对健康构成重大威胁,是世界范围内导致死亡的主要原因之一。暴露于结核分枝杆菌(M.tb)杆菌后,未能清除M.tb的宿主最终处于潜伏结核感染(LTBI)状态,在这种状态下,细菌被遏制但未被消灭。2型糖尿病(DM)是一种非传染性疾病,可削弱宿主免疫力,导致对各种传染病的易感性增加。尽管有许多关于糖尿病和活动性结核病之间关系的研究,但关于糖尿病和LTBI之间关系的数据仍然有限。免疫学数据表明,DM存在的LTBI导致保护性细胞因子和多功能T细胞反应的产生受损,这说明了可能导致活动性结核病风险增加的潜在免疫机制。这篇综述强调了影响人类结核病和糖尿病相互作用的免疫学基础的显著特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Impact of diabetes mellitus on immunity to latent tuberculosis infection.

Tuberculosis (TB) is an infectious disease that poses a major health threat and is one of the leading causes of death worldwide. Following exposure to Mycobacterium tuberculosis (M.tb) bacilli, hosts who fail to clear M.tb end up in a state of latent tuberculosis infection (LTBI), in which the bacteria are contained but not eliminated. Type 2 diabetes mellitus (DM) is a noncommunicable disease that can weaken host immunity and lead to increased susceptibility to various infectious diseases. Despite numerous studies on the relationship between DM and active TB, data on the association between DM and LTBI remains limited. Immunological data suggest that LTBI in the presence of DM leads to an impaired production of protective cytokines and poly-functional T cell responses, accounting for a potential immunological mechanism that could leads to an increased risk of active TB. This review highlights the salient features of the immunological underpinnings influencing the interaction between TB and DM in humans.

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