{"title":"人β防御素-2治疗方式在糖尿病创面治疗中的前瞻性意义。","authors":"Vidyasrilekha Yele, Bharat Kr Sanapalli","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Diabetic Wounds (DW) are a debilitating complication of diabetes. Although various therapeutic strategies are available for DW management, none of them meet all the fundamentals due to the multifaceted pathophysiology of DW. Given the ever-present threat of DW, novel improved therapeutic strategies and the fortification of DW research deserve better prioritization.</p><p><strong>Purpose: </strong>The current review aims to provide the detailed role of human β defensin-2 (HBD-2) in skin wounds with a prospective significance in DW treatment.</p><p><strong>Methods: </strong>This review was conducted through searches of relevant abstracts, research and review articles, and patents, in Scopus, Web of Science, PubMed, Google Scholar, and Clinical Trials databases of English language articles.</p><p><strong>Results: </strong>HBD-2 is a critical innate immune-response protein that defends the human body from infections. Recent reports also support the role of HBD-2 in suppressing inflammation and promoting proliferation and angiogenesis. Based on the literature, its therapeutic administration has been proposed to maintain the equilibrium of systemic homeostasis in DW.</p><p><strong>Conclusion: </strong>It has been hypothesized that HBD-2 could be a crucial modulator for controlling chronic inflammation and size by promoting proliferation and angiogenesis, opening up new therapy options in DW.</p>","PeriodicalId":23741,"journal":{"name":"Wound management & prevention","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment.\",\"authors\":\"Vidyasrilekha Yele, Bharat Kr Sanapalli\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Diabetic Wounds (DW) are a debilitating complication of diabetes. Although various therapeutic strategies are available for DW management, none of them meet all the fundamentals due to the multifaceted pathophysiology of DW. Given the ever-present threat of DW, novel improved therapeutic strategies and the fortification of DW research deserve better prioritization.</p><p><strong>Purpose: </strong>The current review aims to provide the detailed role of human β defensin-2 (HBD-2) in skin wounds with a prospective significance in DW treatment.</p><p><strong>Methods: </strong>This review was conducted through searches of relevant abstracts, research and review articles, and patents, in Scopus, Web of Science, PubMed, Google Scholar, and Clinical Trials databases of English language articles.</p><p><strong>Results: </strong>HBD-2 is a critical innate immune-response protein that defends the human body from infections. Recent reports also support the role of HBD-2 in suppressing inflammation and promoting proliferation and angiogenesis. Based on the literature, its therapeutic administration has been proposed to maintain the equilibrium of systemic homeostasis in DW.</p><p><strong>Conclusion: </strong>It has been hypothesized that HBD-2 could be a crucial modulator for controlling chronic inflammation and size by promoting proliferation and angiogenesis, opening up new therapy options in DW.</p>\",\"PeriodicalId\":23741,\"journal\":{\"name\":\"Wound management & prevention\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Wound management & prevention\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wound management & prevention","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:糖尿病伤口(DW)是一种使人衰弱的糖尿病并发症。虽然有多种治疗策略可用于DW的治疗,但由于DW的病理生理多方位,没有一种治疗策略能满足所有的基本要求。鉴于DW一直存在的威胁,新的改进的治疗策略和DW研究的加强应该得到更好的优先考虑。目的:本文旨在详细研究人β防御素-2 (HBD-2)在皮肤创伤中的作用,为DW治疗提供前瞻性意义。方法:在Scopus、Web of Science、PubMed、Google Scholar和Clinical Trials英文论文数据库中检索相关摘要、研究综述文章和专利。结果:HBD-2是一种重要的先天免疫反应蛋白,可以保护人体免受感染。最近的报道也支持HBD-2在抑制炎症、促进增殖和血管生成方面的作用。根据文献,它的治疗管理已被提出维持DW的系统稳态平衡。结论:假设HBD-2可能是通过促进增殖和血管生成来控制慢性炎症和大小的重要调节剂,为DW开辟了新的治疗选择。
Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment.
Background: Diabetic Wounds (DW) are a debilitating complication of diabetes. Although various therapeutic strategies are available for DW management, none of them meet all the fundamentals due to the multifaceted pathophysiology of DW. Given the ever-present threat of DW, novel improved therapeutic strategies and the fortification of DW research deserve better prioritization.
Purpose: The current review aims to provide the detailed role of human β defensin-2 (HBD-2) in skin wounds with a prospective significance in DW treatment.
Methods: This review was conducted through searches of relevant abstracts, research and review articles, and patents, in Scopus, Web of Science, PubMed, Google Scholar, and Clinical Trials databases of English language articles.
Results: HBD-2 is a critical innate immune-response protein that defends the human body from infections. Recent reports also support the role of HBD-2 in suppressing inflammation and promoting proliferation and angiogenesis. Based on the literature, its therapeutic administration has been proposed to maintain the equilibrium of systemic homeostasis in DW.
Conclusion: It has been hypothesized that HBD-2 could be a crucial modulator for controlling chronic inflammation and size by promoting proliferation and angiogenesis, opening up new therapy options in DW.